宝子们，今天要给大家分享一项超厉害的癌症治疗研究成果😍。科学家们搞出了一种超创新的癌症治疗策略，他们用生物相容性外壳把细菌外膜囊泡（OMVs）包起来，还加了铁离子和超小金纳米颗粒进去，打造出联合肿瘤治疗方案。这个嵌合纳米酶外壳就像给OMVs配上了无敌护盾🛡️，不仅能降低它在血液循环里的毒性，还能让它乖乖跑到肿瘤组织里聚集。等它们到了肿瘤微环境，金纳米颗粒就变身纳米酶小能手🥊，把肿瘤细胞的葡萄糖“吃”掉，还提高过氧化氢水平。升高的过氧化氢和释放的铁离子一反应，就能让肿瘤细胞发生免疫原性死亡。而且，肿瘤相关抗原和OMVs还会一起激活我们身体的免疫系统。这一系列操作下来，就能高效抑制肿瘤啦。希望这个研究能快点应用到临床，让更多癌症患者看到希望呀。

期刊

Advanced Science

标题

Chimeric Nanozyme Bacterial Outer Membrane Vesicles Reprograming Tumor Microenvironment for Safe and Efficient Anticancer Therapy

作者

Fan Zhang, Qianqian Li, Haibing Dai, Weiqun Li, Xiang Chen, Huibin Wu, Shanming Lu, Ran Luo, Feng Li, Guihong Lu, Jianbo Yu, Lin Mei

摘要

This study presents an innovative approach utilizing a biocompatible shell to shield bacterial outer membrane vesicles (OMVs) and incorporate Fe ions and ultrasmall Au nanoparticles to develop a combined tumor therapeutic strategy. These chimeric nanozyme shells effectively reduce the toxicity of OMVs during circulation and promote their accumulation in tumor tissues. In the tumor microenvironment, Au nanoparticles act as nanozymes, catalyzing glucose consumption and elevating H₂O₂ levels. The increased H₂O₂ subsequently reacts with the released Fe ions to induce immunogenic tumor cell death through iron-mediated chemodynamic mechanisms. Simultaneously, the release of tumor-associated antigens and OMVs synergistically stimulates the immune response. This cascade of nanozyme-catalyzed reactions, chemodynamic effects, and immune activation results in efficient tumor inhibition.

原文链接

https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202417712

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静远嘲风（MY Scimage） 成立于2007年，嘲风取自中国传统文化中龙生九子，子子不同的传说，嘲风为守护屋脊之瑞兽，喜登高望远；静远取自成语“宁静致远”，登高莫忘初心，远观而不可务远。

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