宝子们，今天来和大家聊聊胰腺癌里超神秘的细胞——癌症相关成纤维细胞（CAFs）🤔在胰腺导管腺癌（PDAC）发展的时候，CAFs就像缠绕在树上的藤蔓，一直在不断变化。其中有一种CDCP1 + FTL + CAFs，就像带刺的藤蔓一样，对铁死亡诱导剂有超强的抵抗力，铁死亡诱导剂就像啄木鸟，奈何就是啄不动它而且呀，CAFs还会分泌各种化学物质，就像藤蔓上的花朵吸引蝴蝶一样，把髓系细胞吸引过来。髓系细胞的浸润说不定对肿瘤发展有很大影响呢！想知道更多细节的宝子，可以看看Cheng Zhou、Shuguang Tan、Yuxuan Zheng、Hongxia Wang他们写的文章（文章编号2415196）哦，一起探索胰腺癌的奥秘

期刊

Advanced Science

标题

Transcriptome Landscape of Cancer-Associated Fibroblasts in Human PDAC

作者

Mengyu Tao, Wenting Liu, Jianhua Chen, Rujiao Liu, Jianling Zou, Bo Yu, Chenchen Wang, Mingzhu Huang, Qingjian Chen, Zhe Zhang, Zhiyu Chen, Haoyu Sun, Cheng Zhou, Shuguang Tan, Yuxuan Zheng, Hongxia Wang

摘要

Cancer Associated Fibroblasts in Human PDAC

During pancreatic ductal adenocarcinoma (PDAC) progression, cancer-associated fibroblasts (CAFs) undergo dynamic changes, much like vines clinging to trees. The thorny vines represent CDCP1+FTL+ CAFs, which exhibit resistance to ferroptosis inducers (symbolized by the woodpecker). Simultaneously, CAFs secrete various chemokines, akin to blossoms on vines attracting butterflies, thereby promoting the infiltration of myeloid cells. More details can be found in article number 2415196 by Cheng Zhou, Shuguang Tan, Yuxuan Zheng, Hongxia Wang, and co-workers.

原文链接

https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202570155

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