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2025年05月嘲风作品集（二）

已有 211 次阅读 2025-6-30 16:33 |个人分类:作品发表|系统分类:论文交流

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▲ Vol 52 Issue 10 | May 14, 2025

基于像散腔离轴泵浦产生超高阶二维厄米‑高斯模式激光输出

盛泉, 詹德辰, 耿婧旎, 刘天畅, 史春鹏, 付士杰, 史伟, 姚建铨

本文报道了基于像散腔和离轴泵浦的超高阶二维厄米-高斯（HG）模式激光。采用凹面折叠镜向激光谐振腔引入像散，将其本征模式限制为沿像散对称轴方向的HG模式；当泵浦光束在这两个正交方向上均偏离谐振腔光轴时，激光器即以与泵浦光交叠最大的二维HG模式运转。实验中实现了1064 nm Nd∶YVO4激光器最高可达HG214，216的超高阶二维HG模式输出，这是目前已见诸报道的最高阶二维HG模式激光。实验结果与理论计算一致性良好，光场模式阶次灵活可控。

https://www.opticsjournal.net/Articles/OJ560fe02dedb00fd8/Abstract

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▲ Vol 15 Issue 10 | May 16, 2025

Toward an Active Site–Performance Relationship for Oxide-Supported Single and Few Atoms

Duohua Liao, Guo Tian, Fan Xiaoyu, Zhiping Li, Yanyang Sun, Wenxi Chang, Zonglong Li, Liping Li, Chunyang Zeng, Fei Wei, Chenxi Zhang

The directional regulation of product distribution is contingent upon the rational design of catalytically active sites, wherein a lucid comprehension of active site–performance relationships (APR) is indispensable. We employed syngas conversion as a prototypical reaction, and the dynamic evolution of APR across different neighboring density (ND) active sites was elucidated. The variability in APR is predominantly attributed to the alterations in the structure and electronic environment, which induce differential behavior in the adsorption/activation of reactants and the adsorption/desorption of intermediates. As the pivotal rate-limiting step, the adsorption–desorption dynamics of formaldehyde on Mo sites critically govern product distribution; with the increased ND, the product distribution changes from aromatics to low-chain alkanes. Fundamentally, the disparity in adsorption behavior stems from the heterogeneity or homogeneity of the charge environment conferred by the adsorption sites. Moreover, the catalytic reactivity depends on the density and accessibility of the active sites on the catalyst. This study designs a class of syngas conversion catalyst prototypes with active sites at varying ND, elucidating the dynamic evolution of APR and providing a critical theoretical foundation for the selective modulation of catalytic performance.

https://pubs.acs.org/doi/10.1021/acscatal.5c00981

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▲ Vol 97 Issue 19 | May 20, 2025

Rapid Identification of Esophageal Squamous Cell Carcinoma Biomarkers by MALDI-TOF MS Fingerprinting of Extracellular Vesicles

Xiaodan Dai, Huiying Huang, Fei Liu

Esophageal cancer is a major global health challenge, with high incidence and mortality due to the lack of rapid and sensitive diagnostic tools and specific biomarkers. Cancer-cell-derived extracellular vesicles (EVs) carry unique proteins and nucleic acids, making them valuable sources of cancer biomarkers. We report an integrated method that combines an ultrafast exosome isolation system (EXODUS) with matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) to detect EVs and identify protein biomarkers for diagnosing and monitoring esophageal squamous cell carcinoma (ESCC). EVs derived from 20 mL culture medium supernatant of ESCC cells with varying degrees of differentiation serve as analysis models. We use EXODUS to isolate EVs rapidly. We then analyze the intact EVs using MALDI-TOF MS, which provides cell line-specific EV fingerprints in minutes. These protein fingerprints allow the discrimination of ESCC from normal control cells and enable the classification of ESCC based on the degree of cell differentiation. We explore critical EV biomarker peaks for ESCC diagnosis (5555 m/z, 8603 m/z, etc.) and monitoring (2268 m/z, etc.). Potential EV biomarker candidates, including YBX1, DIRAS2, HIST1H2AH, and MYBBP1A, are identified through tandem mass tag (TMT) proteomics. We tentatively assign the protein identities of EV marker peaks by correlation with the TMT proteomics. Applying this method to plasma-derived EVs shows promise for rapid, minimally invasive diagnosis and monitoring of ESCC.

https://pubs.acs.org/doi/10.1021/acs.analchem.4c06273

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