科学家发现一种天然抗氧化剂可以阻止头发变白

诸平

Fig. 1 Researchers from Nagoya University in Japan have identified luteolin, an antioxidant found in certain vegetables, as a potential solution for preventing hair graying. Their study on mice showed that luteolin helped maintain fur color by preserving endothelin expression, which supports melanocyte activity responsible for hair pigmentation.

Fig. 2 Anti-graying effect of external luteolin treatment. Credit: Masashi Kato

据日本名古屋大学（Nagoya University）2025年2月8日提供的消息,抗衰老突破：科学家发现一种天然抗氧化剂可以阻止头发变白（Anti-Aging Breakthrough: Scientists Discover a Natural Antioxidant That Could Stop Gray Hair）。

名古屋大学的一项研究发现，蔬菜中的抗氧化剂木犀草素(luteolin)通过保持内皮素(endothelin)的表达和黑素细胞的活性，有助于防止头发变白。(A study from Nagoya University found that luteolin, an antioxidant in vegetables, helps prevent hair graying by preserving endothelin expression and melanocyte activity.)

头发变白是衰老的常见标志，通常被认为是不可避免的。然而，最近由日本名古屋大学的加藤昌志（Masashi Kato）和香川匠（Takumi Kagawa）领导的一项研究表明，抗氧化剂可能有助于减缓这一过程。相关研究结果于2024年12月6日已经在《抗氧化剂》｛Antioxidants (Basel)｝杂志发表——Machiko Iida（飯田真智子）, Takumi Kagawa（香川匠）, Ichiro Yajima, Akihito Harusato, Akira Tazaki, Delgama A. S. M. Nishadhi, Nobuhiko Taguchi, Masashi Kato（加藤昌志）. Anti-Graying Effects of External and Internal Treatments with Luteolin on Hair in Model Mice. Antioxidants (Basel), 2024, 13(12): 1549. DOI: 10.3390/antiox13121549. Epub. 16 December 2024. 

参与此项研究的有来自日本名古屋大学（Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Japan; Activities of the Institute of Innovation for Future Society, Nagoya University, Nagoya, Japan）、日本楚布大学（Units of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, 1200 Matsumoto-cho, Kasugai-shi, Japan）、日本和裕股份有限公司（General Research and Development Institute, Hoyu Co., Ltd., 1-12 Rouboku, Nagakute-shi, Japan）的研究人员。

研究发现木犀草素（luteolin）是一种天然抗氧化剂，存在于芹菜、西兰花、胡萝卜、洋葱和辣椒等蔬菜中，它可能是防止头发变白的一种物质。这些发现可能会导致头发护理的新应用，旨在保持自然发色。

研究人员研究了3种抗氧化剂即木犀草素（luteolin）、橙皮素（hesperetin）和薯蓣皂苷（diosmetin），以评估它们在老鼠身上的抗变白效果，这些老鼠被培育成像人类一样变白。

不同之处在于，不管木犀草素是外用还是内用，注射木犀草素的老鼠仍然保持着黑色的皮毛，即使它们的笼子同伴的皮毛变成了灰色。

加藤昌志教授说：“这个结果令人惊讶。虽然我们预计抗氧化剂也可能有抗衰老的作用，但只有木犀草素，而不是橙皮素或薯蓣皂苷，显示出显著的作用。这一发现表明木犀草素可能具有防止头发变白的独特功效。”

木犀草素如何起作用：内皮素的作用（How Luteolin Works: The Role of Endothelins）

木犀草素的抗衰老作用与其对内皮素（endothelins）的影响密切相关，而内皮素在细胞通讯中起着至关重要的作用。在研究中，木犀草素处理保留了内皮素及其受体的表达。这种保存支持健康的信号通路，防止通常伴随变灰的黑素细胞活性下降。

“有趣的是，木犀草素对头发周期的影响有限，这表明它的主要影响是色素沉着，而不是头发的生长或脱落，”加藤昌志教授说。“这种有针对性的作用使木犀草素成为解决与年龄有关的头发变白的特别有趣的候选者。”

模型小鼠和人类的头发变白过程之间的相似性为将这些发现转化为人类应用提供了令人鼓舞的前景。和蔬菜一样，木犀草素已经可以作为外用和口服的补充剂，使其成为进一步开发抗衰老治疗的可行候选者。随着研究的进展，这种抗氧化剂可能成为头发护理方案的关键成分，帮助人们随着年龄的增长保持自然的发色。

在这些有希望的结果的基础上，香川匠博士设想木犀草素在年龄相关研究中的更广泛应用。

“木犀草素的抗衰老作用是否也适用于其他与年龄相关的变化，包括秃顶，这将是一项有趣的研究。”

本研究得到了日本教育、文化、体育、科技省的资助（19H01147/Ministry of Education, Culture, Sports, Science and Technology; 23H03147/Ministry of Education, Culture, Sports, Science and Technology; 23K27837/Ministry of Education, Culture, Sports, Science and Technology; 22KK0145/Ministry of Education, Culture, Sports, Science and Technology)

上述介绍仅供参考，欲了解更多信息敬请注意浏览原文和相关报道。

Luteolin, an antioxidant in vegetables, may contribute to the prevention of hair graying

Abstract

Little is known about the anti-graying effects of antioxidants on hair. The anti-graying effects of three antioxidants (luteolin, hesperetin, and diosmetin) on hair were investigated according to the sequential processes of hair graying that were previously clarified in model mice [Ednrb(+/−);RET-mice]. External treatment with luteolin, but not that with hesperetin or diosmetin, alleviated hair graying in Ednrb(+/−);RET-mice. Internal treatment with luteolin also mitigated hair graying in the mice. Although both luteolin treatments had very limited effects on hair cycles, the treatments suppressed the increase in p16^ink4a-positive cells in bulges [senescent keratinocyte stem cells (KSCs)]. Both of the treatments also suppressed decreases in the expression levels of endothelins in KSCs and their receptor (Ednrb) in melanocyte stem cells (MSCs) and alleviated hair graying in the mice. Luteolin is a special antioxidant with an anti-graying potency through improvement of age-related dysfunction in signaling between endothelins in KSCs and their receptor in MSCs. Luteolin for topical and oral use is commercially available to people in the form of supplements. Similar processes of hair graying in Ednrb(+/−);RET-mice and humans have been reported. These results are encouraging for the practical application of luteolin as a medicine with an anti-graying effect on hair in humans.

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