2025年8月15日，国际知名期刊《Analytical Chemistry》在线发表了云南师范大学能源与环境科学学院徐锐教授、张勇教授课题组的最新研究成果《Electrochemiluminescence and Fluorescence Dual-Mode Aptamer Sensor Based on AIEgens-Based Self-Luminous Flower-like MOF for the Detection of Acetamiprid》（中国科学院一区TOP，影响因子IF=6.7）论文链接：https://pubs.acs.org/doi/10.1021/acs.analchem.5c01866，云南师范大学能源与环境科学院为通讯作者单位，论文第一作者为云南师范大学能源与环境科学院硕士研究生李晨晨，通讯作者为徐锐教授、张勇教授。

Abstract

High-performance self-luminous electrochemiluminescence (ECL) materials can effectively improve the sensitivity of ECL sensors. In this study, 4′,4‴,4‴″,4‴‴″-(ethene-1,1,2,2-tetrayl)tetrakis([1,1′-biphenyl]-3-carboxylic acid) (H4ETTC) was used as the organic ligand to prepare self-luminous flower-like aggregation-induced luminescent molecules (AIEgens)-based metal–organic frameworks (MOFs) (Hf NFs) with aggregation-induced electrochemiluminescence (AIECL) and aggregation-induced emission (AIE) properties. H4ETTC as an organic ligand to construct Hf NFs not only increases the loading capacity of the chromophore but also gives them self-luminescence properties, enabling them to produce excellent AIECL responses even without exogenous coreactants. The internally ordered framework structure of Hf NFs restricts the molecular thermal motion of H4ETTC, effectively reducing the generation of nonradiative relaxation. This not only enables Hf NFs to produce stronger AIECL and AIE responses than H4ETTC monomers and aggregates but also improves the ECL efficiency and fluorescence (FL) quantum yield of Hf NFs. Based on the resonance energy transfer (RET) effect, a signal “off-on”-type ECL and FL dual-mode aptamer sensor was constructed with Hf NFs as ECL and FL signal probes and a complex of Prussian blue analogs with polydopamine and gold nanoparticles (NiFe-PBA@PDA@Au) as a quencher to realize the sensitive detection of acetamiprid. This work provides a new avenue for the application of AIEgens-based self-luminous materials in high-performance ECL and FL sensors.

扩展阅读：

张勇

教授，博士生导师，云南省中青年学术与技术带头人后备人才，能源与环境科学学院副院长

学术任职及兼职：

云南省太阳能标准化技术委员会委员；《Chemosensors》（SCI Q1）编委、《当代化工研究》（CA）编委、《Biosensors》（SCI Q1）客座编辑；省生态环境损坏评估专家；省工信厅高级职称评审委员。

主要招生专业：

农业工程、农业工程与信息技术、能源动力、农业生物环境与环境工程、应用化学、化学工程、农业管理、农村发展

主要研究方向：

1.         智能化学传感器件的制备及智慧农业应用

2.         新型功能微纳材料制备及光催化降解污染物应用

3.         农业废弃物高值化利用技术及应用

学历及研究简历：

1997年09月-2001年07月，济南大学，本科生，应用化学专业；

2003年09月-2005年12月，南京工业大学，硕士研究生，应用化学专业

2012年09月-2016年06月，北京理工大学，博士研究生，材料科学与工程专业

2016年08月-2021年12月，济南大学，副教授

2018年12月-2020年12月，美国国立卫生研究院（National Institutes of Health），博士后

2022年01月-2022年12月，云南师范大学，高层次人才引进——第五层次

2022年12月至今，云南师范大学，教授

近五年代表论文和著作：

1.         Chenchen Li, Rui Xu, Xinyu Liu, Lin Tian, Huabin Wang, Yong Zhang*, Qin Wei. Visible self-luminous indium-based metal–organic framework for electrochemiluminescence detection of Hg²⁺.Sensors and Actuators B: Chemical, 2024, 405: 135383.  (SCI Q1，IF = 8.4，ESI高被引)

2.         Jian Nan, Xinyu Liu, Di Zhang, Rui Xu, Yong Zhang*, Qin Wei. Application of Porous Materials in Photocatalytic Treatment of Wastewater. Colloids and Interfaces, 2025, 9(1):3.  (SCI Q2，IF = 2.5)

3.         Xinyu Liu, Chenchen Li, Jian Nan, Ruike Liang, Huabin Wang, Rui Xu*, Yong Zhang*. High-performance TiO₂catalyst composited with In–1,1,2,2-tetra(4-carboxylbiphenyl)ethylene for the efficient degradation of organic pollutants. Environmental Science: Nano, 2024, 11: 1533.  (SCI Q1，IF = 7.3)

4.         Chenchen Li, Bingxin Zhang, Zhourui Wu, Ying Liu, Rui Xu*, Yaoguang Wang, Yong Zhang*, Qin Wei. Multiple signal-enhanced electrochemiluminescence aptamer sensors based on carboxylated ruthenium (II) complexes for acetamiprid detection. Analytica Chimica Acta, 2024, 1309: 342677. (SCI Q1，IF = 5.7)

5.         Bing Li, Yunxiao Li, Chenchen Li, Jinghui Yang, Deling Liu, Huabin Wang, Rui Xu, Yong Zhang* and Qin Wei. An Ultrasensitive Split-Type Electrochemical Immunosensor Based on Controlled-Release Strategy for Detection of CA19-9. Biosensors and Bioelectronics, 2023, 227: 115180. (SCI Q1，IF = 12.545，ESI高被引)

6.         Zhengfang Qu, Yunxiao Li, Rui Xu, Chenchen Li, Huan Wang, Huabin Wang, Yong Zhang* and Qin Wei. Candy-like heterojunction nanocomposite of WO₃/Fe₂O₃ based semiconductor gas sensor for the detection of triethylamine. Microchimica Acta, 2023. (SCI Q1，IF = 6.408)

7.         Chenchen Li, Yunxiao Li, Yong Zhang*, Guanhui Zhao*, Yaoguang Wang, Huabin Wang, Huan Wang, Rui Xu*, Qin Wei. Signal-enhanced electrochemiluminescence strategy using iron-based metal-organic frameworks modified with carboxylated Ru(II) complexes for neuron-specific enolase detection. Biosensors and Bioelectronics, 2022, 215:114605.  (SCI Q1，IF = 12.545)

8.         Yingying Zhang, Tingting Wu, Deling Liu, Rui Xu, Hongmin Ma*, Qin Wei and Yong Zhang*. Photoelectrochemical immunosensor for the sensitive detection of neuron-specific enolase based on the effect of Z-scheme WO₃/NiCo₂O₄ nanoarrays p-n heterojunction. Biosensors and Bioelectronics, 2022, 213:114452. (SCI Q1，IF = 12.545)

9.         Yunxiao Li, Rui Xu*, Huabin Wang, Wumei Xu, Liyan Tian, Jingxin Huang, Chengyue Liang and Yong Zhang*. Recent Advances of Biochar-Based Electrochemical Sensors and Biosensors. Biosensors, 2022, 12: 377. (SCI Q1，IF = 5.743)

10.     Yong Zhang*, Deling Liu, Yingying Zhang, Yanrong Qian, Chenchen Li, Zhengfang Qu, Rui Xu, Qin Wei. Highly sensitive photoelectrochemical neuron specific enolase analysis based on cerium and silver Co-Doped Sb₂WO₆. Biosensors and Bioelectronics, 2022, 203: 114047. (SCI Q1，IF = 12.545)

11.     Yong Zhang*, Haonan Yang, Yanbao Yu*, and Ying Zhang*. Application of nanomaterials in proteomics-driven precision medicine.Theranostics. 2022, 12(6): 2674-2686. (SCI Q1，IF = 11.600)

12.     Yunxiao Li, Jiwei Xu, Rongqi Cheng, Jinghui Yang, Chenchen Li, Yingchun Liu, Rui Xu, Qin Wei and Yong Zhang*, A robust molecularly imprinted electrochemiluminescence sensor based on a Ni-Co nanoarray for the sensitive detection of spiramycin. Analyst, 2022, 147(22): 5178-5186. (SCI Q1，IF = 5.227)

13.     Yingying Zhang, Jingjing Chen, Hui Wang, Qianqian Cui, Wei Da, Yong Zhang, Xiang Ren, Hongmin Ma*, Qin Wei and Huangxian Ju. Novel Photoelectrochemical Biosensing Platform Based on a Double Type II CdLa₂S₄/SnIn₄S₈/Sb₂S₃Ternary Heterojunction as Photoactive Materials and NiCo₂O₄Nanospheres as a Photoquencher for CA19-9 Detection. Analytical Chemistry, 2022, 94(45): 15915-15923. (SCI Q1，IF = 8.008)

14.     Huabin Wang, Ting Cui, Dingxiang Chen, Qiong Luo, Jiwei Xu, Rong Sun, Wenhua Zi, Rui Xu*, Ying Liu* and Yong Zhang*. Hexavalent chromium elimination from wastewater by integrated micro-electrolysis composites synthesized from red mud and rice straw via a facile one-pot method. Scientific Reports, 2022,12: 14242. (SCI Q2，IF = 4.996)

15.     Bing Li, Yong Zhang*, Xiang Ren, Yuyang Li, Huan Wang, Hongmin Ma, Dan Wu, and Qin Wei. A No-washing Point-of-care Electrochemical Biosensor Based on CuS Nanoparticles for Rapid and Sensitive Detection of Neuron-specific Enolase. Electroanalysis, 2022, 34(2): 338-344. (SCI Q3，IF = 3.077)

16.     Chenchen Li, Jinghui Yang, Rui Xu, Huan Wang*, Yong Zhang* and Qin Wei. Progress and Prospects of Electrochemiluminescence Biosensors Based on Porous Nanomaterials.Biosensors, 2022, 12: 508. (SCI Q1，IF = 5.743)

17.     Yaoguang Wang, Yingying Wang, Fangzheng Wang, Hong Chi, Guanhui Zhao, Yong Zhang, Tianduo Li and Qin Wei. Electrochemical aptasensor based on gold modified thiol graphene as sensing platform and gold-palladium modified zirconium metal-organic frameworks nanozyme as signal enhancer for ultrasensitive detection of mercury ions. Journal of Colloid and Interface Science, 2022, 606: 510-517. (SCI Q1，IF = 9.965)

18.     Xianzhen Song, Tingting Wu, Chuannan Luo, Lu Zhao, Xiang Ren, Yong Zhang* and Qin Wei. Peptide-Based Electrochemiluminescence Biosensors Using Silver Nanoclusters as Signal Probes and Pd-Cu₂O Hybrid Nanoconcaves as Coreactant Promoters for Immunoassays. Analytical Chemistry, 2021, 93(38): 13045-13053. (SCI Q1，IF = 8.008)

19.     Deling Liu, Yanrong Qian, Rui Xu, Yong Zhang*, Xiang Ren, Hongmin Ma and Qin Wei. A dual-signal amplification photoelectrochemical immunosensor for ultrasensitive detection of CYFRA 21-1 based on the synergistic effect of SnS₂/SnS/Bi₂S₃and ZnCdS@NPC-ZnO. Sensors and Actuators B: Chemical, 2021, 346: 130456. (SCI Q1，IF =9.221)

20.     Yong Zhang*, Zhaoyi Liu, Yaoguang Wang, Xuan Kuang, Hongmin Ma and Qin Wei. Directly assembled electrochemical sensor by combining self-supported CoNnanoarray platform grown on carbon cloth with molecularly imprinted polymers for the detection of Tylosin. Journal of Hazardous Materials. 2020, 398: 122778. (SCI Q1，IF =14.224)

21.     Bing Li, Yong Zhang*, Xiang Ren, Hongmin Ma, Dan Wu and Qin Wei. No-wash point-of-care biosensing assay for rapid and sensitive detection of aflatoxin B1. Talanta, 2021, 235: 122772. (SCI Q1，IF =6.556)

22.     Rongqi Cheng, Yulong Ding, Yaoguang Wang, Huan Wang, Yong Zhang*, and Qin Wei*. A novel molecularly imprinted electrochemiluminescence sensor based on cobalt nitride nanoarray electrode for the sensitive detection of bisphenol S. RSC Advances, 2021, 11: 11011. (SCI Q2，IF =4.036)

23.     Zhaoyi Liu, Tao Fan, Yong Zhang*, Xiang Ren, Yaoguang Wang, Hongmin Ma and Qin Wei. Electrochemical assay of ampicillin using Fe₃N-Co₂N nanoarraycoated with molecularly imprinted polymer. Microchimica Acta, 2020, 187: 442. (SCI Q1，IF = 6.408)

24.     Zhaoyi Liu, Yong Zhang*, Bing Li, Xiang Ren, Hongmin Ma and Qin Wei*. Novel ratiometric electrochemical sensor for no-wash detection offluorene-9-bisphenol based on combining CoN nanoarrays with molecularly imprinted polymers. Analyst, 2020, 145: 3320-3328. (SCI Q1，IF = 5.227)

25.     Dahai Liu, Zijian Zhou, Xinyu Wang, Hongzhang Deng, Lin Sun, Haixin Lin, Fei Kang, Yong Zhang, Zhantong Wang, Weijing Yang, Lang Rao, Kuikun Yang, Guocan Yu, Jianshi Du, Zheyu Shen and Xiaoyuan Chen. Yolk-shell nanovesicles endow glutathione-responsive concurrent drug release and T-1 MRI activation for cancer theranostics. Biomaterials, 2020, 244: 119979. (SCI Q1，IF = 15.304)

26.     Yong Zhang* and Xiaoyuan Chen*. Nanotechnology and nanomaterial-based no-wash electrochemical biosensors: from design to application. Nanoscale. 2019, 11: 19105. (SCI Q1，IF =8.307)

27.     Zhaoyi Liu, Yong Zhang*, Jinhui Feng, Qingzhi Han and Qin Wei. Ni(OH)₂ nanoarrays based molecularly imprinted polymer electrochemical sensor for sensitive detection of sulfapyridine. Sensors and Actuators B: Chemical, 2019, 287: 551-556. (SCI Q1，IF =9.221)

28.     Yaoguang Wang, Guanhui Zhao,Yong Zhang*, Bin Du and Qin Wei. Ultrasensitive photoelectrochemical immunosensor based on Cu doped TiO₂ compositing with carbon nitride for detection of carcinoembryonic antigen. Carbon, 2019, 146: 276-283. (SCI Q1，IF = 11.307)

29.     南剑, 刘鑫宇, 田林, 徐锐, 官会林, 张勇*. Ni/Co共掺杂二氧化钛纳米片的可控制备及光催化性能研究. 当代化工研究，2024, 03: 163

近五年获奖成果和荣誉称号：

云南省中青年学术与技术带头人后备人才；

云南省引进高层次人才享受政府购房补贴和工作经费资助，二等；

入选全球前2%顶尖科学家终身科学影响力榜单；

入选全球前2%顶尖科学家年度榜单（2022年度、2023年度、2024年度）。

云南省团体标准《玉米秸秆还田种植山药技术规程》T/YNBX 157-2024。

中国商业联合会科学技术奖，科技进步二等奖（第一位）；

河北省科技进步奖，二等奖（第二位）；

山东省省级教学成果奖, 特等奖（第三位）；

山东高等学校优秀科研成果奖，一等奖（第三位）；

中国商业联合会科学技术奖，科技进步一等奖（第一位）。

第二届云南省大学生节能减排社会实践与科技竞赛，特等奖，指导教师；

第三届云南省大学生节能减排社会实践与科技竞赛，二等奖、三等奖，指导教师；

中国国际大学生创新大赛云南赛区，银奖、三等奖，指导教师；

山东省优秀学士学位论文，指导教师；

第四届山东省大学生科技创新大赛，二等奖，指导教师；

第十五届“挑战杯”海尔山东省大学生课外学术科技作品竞赛，二等奖，指导教师。

近五年主持的国家级或百万以上其他项目：

国家重点研发计划项目子课题，主持人，2024-2027；

国家自然科学基金面上项目，主持人，2018-2021；

国家自然科学基金地区基金，主持人，2023-2026；

云南省基础研究专项——重点项目，主持人，2024-2026；

云南师范大学高层次人才引进科研专项，主持人，2022-2026；

罗平县农作物秸秆综合利用重点县建设项目，主持人，2023-2024。

 近五年主持的教学教改及省级以上教学质量工程：

国家级优质案例课堂

云南省一流本科课程，生物质能工程

山东省高校优秀教学成果奖，特等奖（第三位）

近五年主讲课程（研究生、本科生）：

《食品安全与分析》、《食品化学》、《功能纳米材料》、《生物质能源工程》