宝子们，今天来和大家聊聊癌症治疗领域超酷的研究——RNA的m6A修饰与辐射生物学的关系！🧬m6A是RNA上常见的一种化学修饰，你可能想象不到，它在电离辐射和紫外线辐射的场景中扮演着超重要的角色。在癌症组织里，它就像一个“指挥官”，动态调节癌细胞对放疗的敏感度，影响着癌症治疗的效果。而在正常组织中，m6A也没闲着，它参与调控身体对辐射的损伤响应和紫外线暴露带来的毒理效应。这种酶介导的修饰通过影响被修饰RNA的代谢，改变目标基因的表达，进而影响癌症组织的发展和正常组织的辐射反应。科学家们已经发现了m6A修饰的潜力，未来研究要是能深入挖掘，说不定就能找到提高癌症放疗效果、减少正常组织辐射损伤的新策略！这对于癌症患者来说，简直就是希望的星光呀！

期刊

cancer biology&medicine

标题

The interplay between RNA m6A modification and radiation biology of cancerous and non-cancerous tissues: a narrative review

作者

Yajia Cheng, Yue Shang, Shuqin Zhang and Saijun Fan

摘要

investigation. This review summarizes the roles of m6A in the biological effects induced by ionizing radiation and ultraviolet (UV) radiation. It begins with an overview of m6A modification and its detection methods, followed by a detailed examination of how m6A dynamically regulates the sensitivity of cancerous tissues to RT, the injury response in non-cancerous tissues, and the toxicological effects of UV exposure. Notably, this review underscores the importance of novel regulatory mechanisms of m6A and their potential clinical applications in identifying epigenetically modulated radiation-associated biomarkers for cancer therapy and estimation of radiation dosages. In conclusion, enzyme-mediated m6A-modification triggers alterations in target gene expression by affecting the metabolism of the modified RNAs, thus modulating progression and radiosensitivity in cancerous tissues, as well as radiation effects on normal tissues. Several promising avenues for future research are further discussed. This review highlights the importance of m6A modification in the context of radiation biology. Targeting epi-transcriptomic molecules might potentially provide a novel strategy for enhancing the radiosensitivity of cancerous tissues and mitigating radiation-induced injury to normal tissues.

原文链接

https://www.cancerbiomed.org/content/21/12/1120.full

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