在溃疡性结肠炎的研究领域,有一项新发现令人瞩目。大家知道,当人体患上溃疡性结肠炎时,会出现γ - 谷氨酰半胱氨酸(γGC)缺乏的情况,这会引发巨噬细胞铁死亡,进而导致炎症产生。巨噬细胞是我们身体免疫系统的重要成员,铁死亡会让它们无法正常发挥作用,炎症就会越来越严重。不过,科学家们研发出了一种“秘密武器”——带有γGC的爪状结合微粒(γGC - MPs)。这些微粒就像聪明的小战士,能够精准地找到病变部位。到达后,它们会释放出γGC,促进组织对γGC的吸收。这样一来,巨噬细胞的铁死亡就被有效抑制,炎症也能得到缓解。就好比原本肆虐的“小怪兽”被制服了一样。这项研究为溃疡性结肠炎的治疗带来了新的希望,也许在不久的将来,会有更多患者从中受益。
期刊
Advanced Science
标题
Bioinspired Claw-Engaged Adhesive Microparticles Armed with γGC Alleviate Ulcerative Colitis via Targeted Suppression of Macrophage Ferroptosis
作者
Rong Wang, Jianwei Zhu, Jinyi Zhou, Jinyang Li, Min Wang, Yuqi Wu, Danshan Zhao, Xiancheng Chen, Xiaoyuan Chen, Yuetong Wang, Jianhua Zou
摘要
Claw-Engaged Microparticles Armed with γGC Suppress Ferroptosis
γGC deficiency in ulcerative colitis drives macrophage ferroptosis-mediated inflammation. Claw-engaged microparticles armed with γGC (γGC-MPs) enhance lesion targeting, promoting localized γGC release and tissue uptake, thereby inhibiting macrophage ferroptosis. More details can be found in article number 2503903 by Xiancheng Chen, Xiaoyuan Chen, Yuetong Wang, Jianhua Zou, and co-workers. On the cover, Monkey King (Macrophage) armed with Golden Cudgel (Ferroptosis) was bound by the Immortal-Binding Rope and subsequently sealed beneath the Five-Fingered Mountain (γGC-MPs) to prevent his further mischief.
原文链接
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.71155
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