精选
本期【刊•见】为诸位介绍一本生化与分子生物学领域的知名期刊——Journal of Receptors and Signal Transduction。除了对关键指标进行详尽解读外，还向您推荐刊内近三年高被引文章，以及近一年高阅读量文章：
神经性毒剂针对乙酰胆碱酯酶（AChE）的分子对接与毒性研究
基于虚拟筛选与结构描述符建模的 ALK 抑制剂设计及其分子机制探究
N - 甲基 - D - 天冬氨酸受体参与合并甲状腺肿瘤患者焦虑障碍的疾病进展过程
孤儿 G 蛋白偶联受体 75（GPR75）：一个特性独特、尚存争议的潜在治疗靶点
Online ISSN: 1532-4281 Print ISSN: 1079-9893
Journal of Receptors and Signal Transduction发表生物受体及配体相关信号转导通路的最新实验室研究与临床研究成果。研究范围覆盖神经递质、肽类、类固醇、生长因子、细胞因子及药物等广泛方向，从分子机制到疾病诊疗，一刊尽览。
该期刊已被PubMed/MedLine、 Science Citation Index Expanded、SciSearch、Scopus等国际知名数据库收录。
根据JCR显示，JJournal of Receptors and Signal Transduction
在生物化学与分子生物学排名 275/328
在细胞生物学排名 179/207
Scopus根据Scopus显示，Journal of Receptors and Signal Transduction
2025年CiteScore为 5.9
在生物化学、遗传学与分子生物学领域：
生物化学排名 177/448
分子生物学排名 186/414
细胞生物学排名 138/289
中国科学院文献情报中心期刊分区表根据2025年3月20日发布的中国科学院文献情报中心期刊分区表显示：
大类及分区：生物学4区
小类及分区：生化与分子生物学4区，细胞生物学4区
作者须知接收文章类型
本刊以原创论文、综述、迷你综述、简报等多种形式快速传播前沿成果，严格的同行评审确保每篇论文的原创性与学术价值。
覆盖主题包括受体药理学、结构与功能、信号转导机制、分子建模、药物设计策略及受体在疾病诊疗中的应用等。
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编辑团队Journal of Receptors and Signal Transduction 主编由美国北卡罗来纳大学医学院药理学系教授Terry Kenakin担任，编委横跨欧美顶尖高校、诺华、辉瑞等药企研发中心，覆盖受体药理学、G 蛋白偶联受体（GPCR）、信号转导、分子药物研发领域国际权威学者。
主编
Terry Kenakin
Terry Kenakin任职于美国北卡罗来纳大学医学院， 其核心研究方向涵盖 G 蛋白偶联受体（7 跨膜受体，7TMR）药理学理论、变构调控机制与激动剂偏倚信号传导，开展受体亲和力、药效定量建模并搭建药物活性标准化评价体系，同时从事 GPCR 靶向新药研发、临床前药效评估及受体突变功能量化分析，还将分子动力学与新型细胞检测技术运用于候选药物筛选。
作者分布根据JCR显示，近三年在Journal of Receptors and Signal Transduction发文的国家/地区中，发文数量排名前三的有：
中国
印度
沙特阿拉伯
近三年在Journal of Receptors and Signal Transduction发文的全球高校和科研机构中，发文数量排名前三的有：
埃及知识库
沙特阿拉伯哈立德国王大学
南非夸祖鲁-纳塔尔大学
近三年内高被引文章
Molecular docking and toxicity studies of nerve agents against acetylcholinesterase (AChE)
神经性毒剂针对乙酰胆碱酯酶（AChE）的分子对接与毒性研究
作者：Mikael Ham Sembiring et al.
文章摘要：
Acetylcholinesterase (AChE) is a cholinergic enzyme that plays an essential role in the autonomic nervous system. This enzyme is often the target of many nerve agents. When this enzyme is inhibited, its function to hydrolyze acetylcholine is stopped, accumulating the acetylcholine in the tissue and causing prolonged stimulation. Some of the significant nerve agents include sarin (GB), soman (GD), tabun (GA), and venomous agent (VX). In order to determine which compound is the most stable and has the best affinity, the nerve agent venomous agent (VX), sarin (GB), soman (GD), and tabun (GA) are docked to the acetylcholinesterase (AChE) enzyme. After that, toxicity tests will be performed on 17 targets for the compound that was chosen. Autodock Vina 1.2.0 is the software used for the docking procedure. should use the Pymol program version 2.5.4 for analysis and the Ligplot software version 2.2 for visualization of the docking findings. The 'Tox Prediction’ algorithm from Insilico was used to determine the toxicity of various substances. Based on the results of molecular docking, the free binding energy of Donepezil, sarin (GB), soman (GD), tabun (GA), and venomous agent (VX) in kcal/mol are −12,3, −4.8, −6.0, −5,1, and −6.3 respectively. Finally, four ligands bind strongly to the receptor Donepezil at RMSD 0.327 Å, and the venomous agent (VX) compound binds the most strongly compared to the other test ligands. Furthermore, in the toxicity test of Compound VX, which exhibits neurotoxic activity, no toxic activity was observed on specific organs and targets.
基于虚拟筛选与结构描述符建模的 ALK 抑制剂设计及其分子机制探究
作者：Ya-Kun Zhang et al.
文章摘要：
To address the challenges of target specificity and drug resistance in Anaplastic lymphoma kinase (ALK) inhibition, this study conducted a virtual screening of the BindingDB database, yielding 711 potential ALK inhibitors. Four QSAR models were established using structural clustering and machine learning to elucidate structure–activity relationships. Through substituent fragment optimization, 72 highly active compounds were designed, among which four promising candidates were identified based on ADMET predictions, retrosynthetic analyses and molecular docking analyses. Molecular dynamics simulations and binding free energy calculations further characterized their binding mechanisms. These findings provide a theoretical framework for the rational design of next-generation ALK inhibitors.
近一年内高阅读量文章
N - 甲基 - D - 天冬氨酸受体参与合并甲状腺肿瘤患者焦虑障碍的疾病进展过程
作者：Meilan Su et al.
文章摘要：
Background
Anxiety disorders (ADs) and thyroid tumors (TTs) are prevalent and frequently co-occur. Previous studies suggest that the N-methyl-d-aspartate receptor (NMDAR) may play a role in their co-occurrence, but the understanding of their relationship is not comprehensive. The aim of this study was to investigate the role of NMDAR in the progression of animal models of AD with TT.
Methods
We developed an animal model of AD with TT in Balb/c mice using chronic unpredictable mild stress (CUMS) combined with subcutaneous IHH4 cell xenotransplantation. Mice were treated with d-serine and MK-801 to assess behavioral changes and tumor growth. The expression of NMDAR subunits in the thyroid and transplanted TT tissues was also analyzed.
Results
The combination of CUMS and IHH4 cell xenotransplantation helped successfully create an AD with TT model, which exhibited stable anxiety-like behavior, a high tumor formation rate, and ease of implementation. d-Serine alleviated anxiety behaviors but increased NR2A subunit activity in both thyroid and TT tissues, disrupted the normal structure of the thyroid, and accelerated TT growth. In contrast, MK-801 had the opposite effect.
Conclusions
NMDAR, particularly the NR2A subunit, plays a crucial role in TT progression associated with AD. In the clinical drug selection for the patients with ADs with concomitant TT, special attention should be paid to the two-sidedness of drugs. The CUMS and IHH4 xenotransplantation model is an effective tool for studying AD with TT.
孤儿G蛋白偶联受体75 (GPR75）：一个特性独特、尚存争议的潜在治疗靶点
作者：Teodora Stratulat et al.
文章摘要：
G protein-coupled receptors (GPCRs) are a large and diverse superfamily of membrane proteins that mediate cellular responses to a wide range of stimuli, making them critical players in a variety of physiological and pathological processes. Despite their recognized therapeutic potential, many GPCRs are still considered orphans, their ligands and biological functions remaining unknown. Among these, GPR75 has garnered increasing attention due to its high expression in the brain and retina and its proposed roles in cardiovascular function, metabolism, and cancer. Recent studies have suggested several potential endogenous ligands for GPR75, including 20-HETE and RANTES/CCL5, but their status as true receptor agonists remains controversial. Here, we summarize the current state of knowledge regarding GPR75, from its discovery and evolutionary context to its expression profile, putative ligands, and emerging physiological functions. Understanding the role of GPR75 may offer new therapeutic avenues for neurological disorders, metabolic diseases, and cancer.
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