虚拟专辑简介
The microbiota, a complex ecosystem of microorganisms residing within hosts, plays a crucial role in modulating health, aging, and disease. This virtual collection compiles six key articles that delve into the diverse functions of the microbiota, from its impact on host immunity and metabolism to its potential in delaying aging and treating various diseases. The collection also explores the microbiota's role in high-altitude adaptation, highlighting its bidirectional effects on host health. Collectively, these articles underscore the microbiota's significance in human health and diseases, offering new insights and therapeutic avenues for future research.
好文速读
1. Fecal microbiota transplantation: A new strategy to delay aging
hLife Perspective | 粪菌移植：延缓衰老之“新策略”
通讯作者：刘光慧，任捷
本研究系统总结了粪菌移植在衰老研究中的最新进展：与老年人或患病个体相比，年轻个体的肠道微生物群对宿主有益；当寿命较长物种的肠道微生物群移植到寿命较短的物种中时，也会对宿主产生有益影响。
引用：
Yan H, Ren J, Liu GH. Fecal microbiota transplantation: A new strategy to delay aging. hLife 2023; 1: 8–11.
2. Fecal microbiota transplantation in clinical practice: Present controversies and future prospects
hLife Review | 肠菌移植疗法的应用困境及破局之法
通讯作者：秦环龙，陈启仪
本论文结合国际上最新发布的FMT临床试验结果和上海十院肠道微生态诊疗中心近万例临床实践数据，开创性提出了FMT疗法对肠内和肠外疾病的治疗响应规律，重点讨论了当前FMT临床应用中所存在的争议以及治疗过程中影响患者预后的关键因素，详细探讨了大数据平台对于现状的“破局”作用以及临床应用中的实践结果和未来前景。
引用：Tian H, Wang X, Fang Z, et al. Fecal microbiota transplantation in clinical practice: Present controversies and future prospects. hLife 2024; 2: 269–283.
3. Regulatory functions and mechanisms of human microbiota in infectious diseases
hLife Review | 人体微生物群在感染性疾病中的调控功能与作用机制
通讯作者：柴琪瑶，刘翠华，张令强
本论文系统综述了微生物群、人类宿主和病原体三维调控网络在感染性疾病中的调控功能和作用机制，以及外界环境因素对此过程的动态影响，并深入探讨了基于人体微生物群开发感染性疾病诊断、预防和治疗新手段的新思路与新策略。
引用：
Fang Y, Lei Z, Zhang L, et al. Regulatory functions and mechanisms of human microbiota in infectious diseases. hLife 2024; 2: 496–513.
4. Altitude adaptation: The unseen work of gut microbiota
hLife | 高原适应新视角：肠道菌群的作用及潜力通讯作者：杨瑞馥，毕玉晶本文章系统综述了肠道菌群与高原适应方向的研究进展，以期为改善高原反应提供理论支撑。
引用：
Guo J, Zhao R, Li K, et al. Altitude adaptation: The unseen work of gut microbiota. hLife 2025; 3: 5–20.
5. Reconciling host-microbiota metabolic incompatibility safeguards male fertility
hLife Article | 肠道菌群与宿主代谢的兼容性：揭秘对雄性生育力的影响
通讯作者：彭敏
本研究揭示了ACSS1和ACSS2缺陷的雄性小鼠由于乙酸水平升高和代谢性酸中毒而导致不育，深入探讨了肠道菌群、代谢和生殖之间的关联。
引用：Shang Q, Li Z, Yin N, et al. Reconciling host-microbiota metabolic incompatibility safeguards male fertility. hLife 2024; 2: 284–295.
通讯作者：秦楠
On June 22nd-25th, 2024, the 10th International Human Microbiome Consortium (IHMC) congress was successfully held in Rome, Italy, which aimed to promote an ever-increasing interchange between industrial and scientific partners, as well as to expand the number of participants from different study categories, and was chaired by Professor Alessio Fasano, a professor of Pediatrics and Nutrition, Harvard Medical School, and co-chaired by Professor Maria Vasile from the European Commission. The conference focused on important topics such as “The interaction of the human holobiont with other bionts” “Environmental factors influencing the human holobiont” “Oncobiome: A network introducing gut microbiota into oncology” and “Microbiome and cancer development”. This conference included themed presentations by 121 scholars and industry experts from over 30 countries around the world, which introduced their research topics and latest research achievements to the audience, and over 1000 scholars attended the event on-site.
引用：
Qin N, Ehrlich SD. Advancements for microbiome research in human health and disease: From composition to functionality. hLife 2024; 2: 542–545.
期刊简介
hLife由高福院士、董晨院士和Jules A. Hoffmann教授（2011诺奖获得者）领衔，是中国科学院微生物研究所主办，中国生物工程学会，浙江大学陈廷骅大健康学院，西湖大学医学院，上海市免疫治疗创新研究院和广州霍夫曼免疫研究所联合支持，与国际出版商爱思唯尔合作的健康科学领域综合性英文期刊。
hLife聚焦健康科学领域的前沿进展，旨在促进基础研究与临床应用的融合发展。期刊发表与医学相关各研究领域最新成果，学科领域包括（但不限于）病原生物学、流行病学、生理学、免疫学、结构生物学、疾病监测、肿瘤、药物、疫苗和健康政策等。
hLife是一本金色开放获取期刊，月刊出版；2022年成功入选“中国科技期刊卓越行动计划高起点新刊”；2023年11月正式创刊; 2024年5月被DOAJ收录；2024年8月被Scopus收录。
2026年前hLife接收的稿件免收文章处理费（APC）。
期刊网址：
https://www.sciencedirect.com/journ
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