马蒂亚斯·曼多弗荣获欧洲联合胃肠病学新星奖
诸平
![image (1).jpg](http://image.sciencenet.cn/home/202311/01/200833japdicc1ce7eadca.jpg)
图1 马蒂亚斯·曼多弗(Mattias Mandorfer | M.D. Ph.D. |)
据奥地利维也纳医科大学(Medical University of Vienna简称MedUni Vienna)2023年10月31日提供的消息,马蒂亚斯·曼多弗 (Mattias Mandorfer) 荣获欧洲联合胃肠病学新星奖(Mattias Mandorfer honoured with the United European Gastroenterology Rising Star Award)。
马蒂亚斯·曼多弗是维也纳医科大学(Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria)的胃肠病学家(gastroenterologist)和肝病学家(hepatologist),也是维也纳医科大学维也纳肝脏血流动力学实验室(Vienna Hepatic Hemodynamic Lab at MedUni Vienna)的负责人,在丹麦首都哥本哈根(Copenhagen)举行的欧洲联合胃肠病学 (United European Gastroenterology简称UEG) 周(UEG Week)上荣获新星奖(Rising Star Award)。该奖项每年由专业协会颁发给欧洲最有前途的、新兴的基础、转化和临床科学家。它为这些年轻的研究人员进一步发展他们的职业生涯提供了一个持久的平台。获奖者由UEG国家协会委员会(UEG National Societies Committee)和UEG科学委员会(UEG Scientific Committee)根据国际质量研究和发展科学独立性的记录联合选出。
该奖项附带的演讲标题深入了解了马蒂亚斯·曼多弗的研究重点:“去除主要病因后的肝硬化”("Cirrhosis after removal of the primary aetiological factor")。肝硬化也称为慢性肝病的终末期。由此产生的门静脉高压(portal hypertension)会增加腹水和静脉曲张出血等并发症的风险。然而,对肝硬化患者的观察表明,肝损伤的根本原因可以被消除,这绝不是一条单行道。马蒂亚斯·曼多弗及其同事从已经患有肝硬化且接受现代丙型肝炎治疗的患者身上获得了这一见解。
维也纳肝脏血流动力学实验室(Vienna Hepatic Hemodynamic Lab)对肝静脉压梯度(hepatic venous pressure gradient简称HVPG)的微创测量显示,大多数患者的门静脉高压得到改善,这意味着并发症的风险降低。
虽然维也纳医科大学的研究得出结论,门静脉高压的严重程度和并发症的风险也可以通过非侵入性方法来评估,例如使用瞬时弹性成像测量肝脏硬度或计算 VITRO 评分,但由于结果不一致,这一发现最初仍然存在争议。
然而,巴韦诺合作(Baveno Cooperation)组织的一项分析证明了无创检查的诊断和预后价值,由此产生的无创标准导致了由马蒂亚斯·曼多弗主持的巴韦诺VII共识(Baveno VII Consensus)——门静脉高压管理国际标准——章节的相应建议。此外,在国际合作的框架内,开发了一种对丙型肝炎治愈后肝细胞癌风险进行分层的算法,目前正在长期研究中与门静脉高压的非侵入性标准一起进行验证。因此,马蒂亚斯·曼多弗的团队不仅能够为这些患者的个性化护理做出重大贡献,而且还为晚期肝病/肝硬化的消退提供了重要的见解。
除了针对晚期肝病/肝硬化的病因治疗外,维也纳医科大学还对门静脉高压症本身的药物治疗进行深入研究:例如,维也纳肝血流动力学实验室在门静脉高压微创和无创评估方面的专业知识,还为路德维希·玻尔兹曼协会临床研究小组(Ludwig Boltzmann Society Clinical Research Group)“门脉高压患者的疾病驱动机制”("Disease-driving mechanisms in patients with portal hypertension")正在进行的三项临床试验提供有效性终点,该小组目前由托马斯·赖伯杰(Thomas Reiberger)领导,从2027年起将由马蒂亚斯·曼多弗领导。
马蒂亚斯·曼多弗的个人资料简介
马蒂亚斯·曼多弗在维也纳和海德堡(Heidelberg)学习过人类医学,并于2012年毕业。在2017年完成N790研究(N790 studies)并于2018年完成训练后,他于2019年1~9月在巴塞罗那肝脏血流动力学实验室(Clinical & Research Fellowship, Barcelona Hepatic Hemodynamic Lab, Liver Unit)出国留学。2021年履行了内部职业协议之后,他接管了维也纳肝脏血流动力学实验室的领导权,该实验室目前在门静脉高压领域处于世界领先地位。马蒂亚斯·曼多弗是250篇 PubMed 收录文章(250 PubMed-listed articles)的作者,顶级期刊JHEP Rep的副编辑(Associate Editor),并且是/曾经是《肠胃病学》(Gastroenterology)、《肝脏病学杂志》(J Hepatol)、《美国肠胃病学杂志》(Am J Gastroenterol)以及《肝脏国际》(Liver International)的编辑委员会成员。除了担任奥地利胃肠病学和肝病学会 (Austrian Society of Gastroenterology and Hepatology,ÖGGH) 2019-2023 年第一秘书、肝病学工作组组长和继续教育顾问的国内活动外,马蒂亚斯·曼多弗在国际上也非常活跃。除此之外,他还是巴韦诺合作组织指导委员会和研究委员会(Steering Committee and the Research Committee of the Baveno Cooperation)的成员,并担任该组织的财务主管。此外,他还是欧洲肝脏研究协会(European Association for the Study of the Liver, EASL)青年研究者工作组的成员,并参与该协会临床实践指南(Clinical Practice Guidelines的制定。
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图2 Dimensions数据库统计结果
Dimensions数据库高引(被引频次>100次)论文
Roberto de Franchis, Jaime Bosch, Guadalupe Garcia-Tsao, Thomas Reiberger, Cristina Ripoll, Baveno VII Faculty, Juan G. Abraldes, Agustin Albillos, Anna Baiges, Jasmohan Bajaj, Rafael Bañares, Marta Barrufet, Lina Benajiba, Annalisa Berzigotti, Christophe Bureau, Vincenza Calvaruso, Andres Cardenas, Gennaro D’Amico, Andrea De Gottardi, Alessandra Dell’Era, Angels Escorsell, Jonathan Fallowfield, Hector Ferral, Sven Francque, Ron Gaba, Juan Carlos Garcia-Pagàn, Joan Genescà, Susana Gomes Rodrigues, Jordi Gracia-Sancho, Guogong Han, Virginia Hernandez-Gea, Jidong Jia, Jean Jacques Kiladjian, Aleksander Krag, Wim Laleman, Vincenzo La Mura, Sabela Lens, Xuefeng Luo, Mattias Mandorfer, Sarwa Darwish Murad, Valerie Paradis, David Patch, Salvatore Piano, Massimo Pinzani, Aurelie Plessier, Massimo Primignani, Bogdan Procopet, Pierre Emmanuel Rautou, Marika Rudler, Shiv K. Sarin, Filippo Schepis, Marco Senzolo, Vijay Shah, Akash Shukla, Puneeta Tandon, Luis Tellez, Dominique Thabut, Maja Thiele, Jonel Trebicka, Dhiraj Tripathi, Emmanouil Tsochatzis, Laura Turco, Fanny Turon, Dominique Valla, Candid Villanueva, Ian Wanless, Hitoshi Yoshiji
2021, Journal of Hepatology - Article
To expand on the work of previous meetings, a virtual Baveno VII workshop was organised for October 2021. Among patients with compensated cirrhosis or compensated advanced chronic liver disease (cACLD...more
Mattias Mandorfer, Simona Bota, Philipp Schwabl, Theresa Bucsics, Nikolaus Pfisterer, Matthias Kruzik, Michael Hagmann, Alexander Blacky, Arnulf Ferlitsch, Wolfgang Sieghart, Michael Trauner, Markus Peck-Radosavljevic, Thomas Reiberger
2014, Gastroenterology - Article
BACKGROUND & AIMS: <AbstractText Label="BACKGROUND & AIMS" NlmCategory="OBJECTIVE">Nonselective β blockers (NSBBs) reduce portal pressure and the risk for varicea...more
Thomas Reiberger, Arnulf Ferlitsch, Berit A. Payer, Mattias Mandorfer, Birgit B. Heinisch, Hubert Hayden, Frank Lammert, Michael Trauner, Markus Peck-Radosavljevic, Harald Vogelsang, Vienna Hepatic Hemodynamic Lab
2012, Journal of Hepatology - Article
BACKGROUND & AIMS: <AbstractText Label="BACKGROUND & AIMS" NlmCategory="OBJECTIVE">We evaluated the gastrointestinal permeability and bacterial translocation in c...more
Jonel Trebicka, Javier Fernandez, Maria Papp, Paolo Caraceni, Wim Laleman, Carmine Gambino, Ilaria Giovo, Frank Erhard Uschner, Cesar Jimenez, Rajeshwar Mookerjee, Thierry Gustot, Agustin Albillos, Rafael Bañares, Martin Janicko, Christian Steib, Thomas Reiberger, Juan Acevedo, Pietro Gatti, William Bernal, Stefan Zeuzem, Alexander Zipprich, Salvatore Piano, Thomas Berg, Tony Bruns, Flemming Bendtsen, Minneke Coenraad, Manuela Merli, Rudolf Stauber, Heinz Zoller, José Presa Ramos, Cristina Solè, Germán Soriano, Andrea de Gottardi, Henning Gronbaek, Faouzi Saliba, Christian Trautwein, Osman Cavit Özdogan, Sven Francque, Stephen Ryder, Pierre Nahon, Manuel Romero-Gomez, Hans Van Vlierberghe, Claire Francoz, Michael Manns, Elisabet Garcia, Manuel Tufoni, Alex Amoros, Marco Pavesi, Cristina Sanchez, Anna Curto, Carla Pitarch, Antonella Putignano, Esau Moreno, Debbie Shawcross, Ferran Aguilar, Joan Clària, Paola Ponzo, Christian Jansen, Zsuzsanna Vitalis, Giacomo Zaccherini, Boglarka Balogh, Victor Vargas, Sara Montagnese, Carlo Alessandria, Mauro Bernardi, Pere Ginès, Rajiv Jalan, Richard Moreau, Paolo Angeli, Vicente Arroyo, PREDICT STUDY group of the EASL-CLIF Consortium, Miriam Maschmeier, David Semela, Laure Elkrief, Ahmed Elsharkawy, Tamas Tornai, Istvan Tornai, Istvan Altorjay, Agnese Antognoli, Maurizio Baldassarre, Martina Gagliardi, Eleonora Bertoli, Sara Mareso, Alessandra Brocca, Daniela Campion, Giorgio Maria Saracco, Martina Rizzo, Jennifer Lehmann, Alessandra Pohlmann, Michael Praktiknjo, Robert Schierwagen, Elsa Solà, Nesrine Amari, Miguel Rodriguez, Frederik Nevens, Ana Clemente, Peter Jarcuska, Alexander Gerbes, Mattias Mandorfer, Christoph Welsch, Emanuela Ciraci, Vish Patel, Cristina Ripoll, Adam Herber, Paul Horn, Karen Vagner Danielsen, Lise Lotte Gluud, Jelte Schaapman, Oliviero Riggio, Florian Rainer, Jörg Tobiasch Moritz, Mónica Mesquita, Edilmar Alvarado-Tapias, Osagie Akpata, Peter Lykke Eriksen, Didier Samuel, Sylvie Tresson, Pavel Strnad, Roland Amathieu, Macarena Simón-Talero, Francois Smits, Natalie van den Ende, Javier Martinez, Rita Garcia, Daniel Markwardt, Harald Rupprechter, Cornelius Engelmann
2020, Journal of Hepatology - Article
BACKGROUND & AIMS: <AbstractText Label="BACKGROUND & AIMS">Acute decompensation (AD) of cirrhosis is defined as the acute development of ascites, gastrointestinal hemorrhag...more
Mattias Mandorfer, Karin Kozbial, Philipp Schwabl, Clarissa Freissmuth, Rémy Schwarzer, Rafael Stern, David Chromy, Albert Friedrich Stättermayer, Thomas Reiberger, Sandra Beinhardt, Wolfgang Sieghart, Michael Trauner, Harald Hofer, Arnulf Ferlitsch, Peter Ferenci, Markus Peck-Radosavljevic
2016, Journal of Hepatology - Article
BACKGROUND & AIMS: <AbstractText Label="BACKGROUND & AIMS">We aimed to investigate the impact of sustained virologic response (SVR) to interferon (IFN)-free therapies on po...more
Macarena Simón-Talero, Davide Roccarina, Javier Martínez, Katharina Lampichler, Anna Baiges, Gavin Low, Elba Llop, Michael Praktiknjo, Martin H. Maurer, Alexander Zipprich, Michela Triolo, Guillaume Vangrinsven, Rita Garcia-Martinez, Annette Dam, Avik Majumdar, Carmen Picón, Daniel Toth, Anna Darnell, Juan G. Abraldes, Marta Lopez, Guido Kukuk, Aleksander Krag, Rafael Bañares, Wim Laleman, Vincenzo La Mura, Cristina Ripoll, Annalisa Berzigotti, Jonel Trebicka, Jose Luis Calleja, Puneeta Tandon, Virginia Hernandez-Gea, Thomas Reiberger, Agustín Albillos, Emmanuel A. Tsochatzis, Salvador Augustin, Joan Genescà, Baveno VI-SPSS group from the Baveno Cooperation, Sergi Quiroga, Dominic Yu, Luis Téllez, Mattias Mandorfer, Juan Carlos Garcia-Pagan, Claudia Berbel, Jose Ferrusquia, Michel Ble, Mari Angeles Garcia-Criado, Ernest Belmonte, Michael Ney, Cristina Margini, Stefania Casu, Giuseppe Murgia, Christiane Ludwig, Martin Rönsch, Dietrich Stoevesandt, Laura Carrion, Enrique Ramón Botella
2018, Gastroenterology - Article
BACKGROUND & AIMS: <AbstractText Label="BACKGROUND & AIMS">Spontaneous portosystemic shunts (SPSS) have been associated with hepatic encephalopathy (HE). Little is known ab...more
Patrick Ingiliz, Thomas C. Martin, Alison Rodger, Hans-Jürgen Stellbrink, Stefan Mauss, Christoph Boesecke, Mattias Mandorfer, Julie Bottero, Axel Baumgarten, Sanjay Bhagani, Karine Lacombe, Mark Nelson, Jürgen K. Rockstroh, NEAT study group
2016, Journal of Hepatology - Article
BACKGROUND & AIMS: <AbstractText Label="BACKGROUND & AIMS">Moderate cure rates of acute hepatitis C virus (HCV) infections with pegylated interferon and ribavirin have been...more
Jonel Trebicka, Javier Fernandez, Maria Papp, Paolo Caraceni, Wim Laleman, Carmine Gambino, Ilaria Giovo, Frank Erhard Uschner, Christian Jansen, Cesar Jimenez, Rajeshwar Mookerjee, Thierry Gustot, Agustin Albillos, Rafael Bañares, Peter Jarcuska, Christian Steib, Thomas Reiberger, Juan Acevedo, Pietro Gatti, Debbie L. Shawcross, Stefan Zeuzem, Alexander Zipprich, Salvatore Piano, Thomas Berg, Tony Bruns, Karen Vagner Danielsen, Minneke Coenraad, Manuela Merli, Rudolf Stauber, Heinz Zoller, José Presa Ramos, Cristina Solé, Germán Soriano, Andrea de Gottardi, Henning Gronbaek, Faouzi Saliba, Christian Trautwein, Haluk Tarik Kani, Sven Francque, Stephen Ryder, Pierre Nahon, Manuel Romero-Gomez, Hans Van Vlierberghe, Claire Francoz, Michael Manns, Elisabet Garcia-Lopez, Manuel Tufoni, Alex Amoros, Marco Pavesi, Cristina Sanchez, Michael Praktiknjo, Anna Curto, Carla Pitarch, Antonella Putignano, Esau Moreno, William Bernal, Ferran Aguilar, Joan Clària, Paola Ponzo, Zsuzsanna Vitalis, Giacomo Zaccherini, Boglarka Balogh, Alexander Gerbes, Victor Vargas, Carlo Alessandria, Mauro Bernardi, Pere Ginès, Richard Moreau, Paolo Angeli, Rajiv Jalan, Vicente Arroyo, PREDICT STUDY group of the EASL-CLIF CONSORTIUM, Miriam Maschmeier, David Semela, Laure Elkrief, Ahmed Elsharkawy, Tamas Tornai, Istvan Tornai, Istvan Altorjay, Agnese Antognoli, Maurizio Baldassarre, Martina Gagliardi, Eleonora Bertoli, Sara Mareso, Alessandra Brocca, Daniela Campion, Giorgio Maria Saracco, Martina Rizzo, Jennifer Lehmann, Alessandra Pohlmann, Maximilian J. Brol, Johannes Chang, Robert Schierwagen, Elsa Solà, Nesrine Amari, Miguel Rodriguez, Frederik Nevens, Ana Clemente, Martin Janicko, Daniel Markwardt, Mattias Mandorfer, Christoph Welsch, Tanja M. Welzel, Emanuela Ciraci, Vish Patel, Cristina Ripoll, Adam Herber, Paul Horn, Flemming Bendtsen, Lise Lotte Gluud, Jelte Schaapman, Oliviero Riggio, Florian Rainer, Jörg Tobiasch Moritz, Mónica Mesquita, Edilmar Alvarado-Tapias, Osagie Akpata, Luise Aamann, Didier Samuel, Sylvie Tresson, Pavel Strnad, Roland Amathieu, Macarena Simón-Talero, Francois Smits, Natalie van den Ende, Javier Martinez, Rita Garcia, Harald Rupprechter, Cornelius Engelmann, Osman Cavit Özdogan
2020, Journal of Hepatology - Article
BACKGROUND & AIMS: <AbstractText Label="BACKGROUND & AIMS">Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD-No ACLF), or...more
Thomas Reiberger, Andreas Püspök, Maria Schoder, Franziska Baumann-Durchschein, Theresa Bucsics, Christian Datz, Werner Dolak, Arnulf Ferlitsch, Armin Finkenstedt, Ivo Graziadei, Stephanie Hametner, Franz Karnel, Elisabeth Krones, Andreas Maieron, Mattias Mandorfer, Markus Peck-Radosavljevic, Florian Rainer, Philipp Schwabl, Vanessa Stadlbauer, Rudolf Stauber, Herbert Tilg, Michael Trauner, Heinz Zoller, Rainer Schöfl, Peter Fickert
2017, Wiener klinische Wochenschrift - Article
The Billroth III guidelines were developed during a consensus meeting of the Austrian Society of Gastroenterology and Hepatology (ÖGGH) and the Austrian Society of Interventional Radiology (ÖGIR) held...more
Thomas Reiberger, Mattias Mandorfer
2016, Journal of Hepatology - Article
Non-selective betablockers (NSBBs) remain the cornerstone of medical treatment of portal hypertension. The evidence for their efficacy to prevent variceal bleeding is derived from prospective trials, ...more
Philipp Schwabl, Simona Bota, Petra Salzl, Mattias Mandorfer, Berit A. Payer, Arnulf Ferlitsch, Judith Stift, Friedrich Wrba, Michael Trauner, Markus Peck‐Radosavljevic, Thomas Reiberger
2014, Liver International - Article
BACKGROUND & AIMS: <AbstractText Label="BACKGROUND & AIMS" NlmCategory="OBJECTIVE">Transient elastography (TE) can non-invasively diagnose cirrhosis and portal hy...more
Mattias Mandorfer, Karin Kozbial, Philipp Schwabl, David Chromy, Georg Semmler, Albert F. Stättermayer, Matthias Pinter, Virginia Hernández‐Gea, Monika Fritzer‐Szekeres, Petra Steindl‐Munda, Michael Trauner, Markus Peck‐Radosavljevic, Juan C. García‐Pagán, Peter Ferenci, Thomas Reiberger
2019, Hepatology - Article
BACKGROUND AND AIMS: Sustained virologic response (SVR) to interferon (IFN)-free therapies ameliorates portal hypertension (PH); however, it remains unclear whether a decrease in hepatic venous pressu...more
Bernhard Scheiner, Katharina Pomej, Martha M Kirstein, Florian Hucke, Fabian Finkelmeier, Oliver Waidmann, Vera Himmelsbach, Kornelius Schulze, Johann von Felden, Thorben W Fründt, Marc Stadler, Harald Heinzl, Kateryna Shmanko, Stephan Spahn, Pompilia Radu, Alexander R Siebenhüner, Joachim C Mertens, Nuh N Rahbari, Fabian Kütting, Dirk-Thomas Waldschmidt, Matthias P Ebert, Andreas Teufel, Sara De Dosso, David J Pinato, Tiziana Pressiani, Tobias Meischl, Lorenz Balcar, Christian Müller, Mattias Mandorfer, Thomas Reiberger, Michael Trauner, Nicola Personeni, Lorenza Rimassa, Michael Bitzer, Jörg Trojan, Arndt Weinmann, Henning Wege, Jean-François Dufour, Markus Peck-Radosavljevic, Arndt Vogel, Matthias Pinter
2021, Journal of Hepatology - Article
BACKGROUND & AIMS: <AbstractText Label="BACKGROUND & AIMS">Immunotherapy with atezolizumab plus bevacizumab represents the new standard of care in systemic front-line treat...more
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