小柯机器人

澳大利亚墨尔本大学Elizabeth L. Christie研究团队完成同源重组缺失的晚期高级别浆液性卵巢癌的多组学分析。该项研究成果于2023年2月27日在线发表在《自然—遗传学》杂志上。

研究人员表示，高级别的浆液性卵巢癌（HGSC）经常以同源重组（HR）DNA修复缺陷为特征，虽然大多数这样的肿瘤对初始治疗很敏感，但获得性耐药是常见的。

研究人员采取了一种多组学方法，利用从15名患有HR缺陷的HGSC妇女身上收集的多个尸检样本，来研究疾病末期的分子多样性。患者有多克隆疾病，在大多数患者中发现了几种抗性机制，包括逆转突变和通过其他方式恢复HR。研究人员还观察到频繁的全基因组重复和免疫成分的全面变化，并有证据表明免疫逃逸。这项分析突出了HGSC内部的各种演化变化，这些变化逃避了治疗，并最终压倒了个别患者。

附：英文原文

Title: Multiomic analysis of homologous recombination-deficient end-stage high-grade serous ovarian cancer

Author: Burdett, Nikki L., Willis, Madelynne O., Alsop, Kathryn, Hunt, Allison L., Pandey, Ahwan, Hamilton, Phineas T., Abulez, Tamara, Liu, Xuan, Hoang, Therese, Craig, Stuart, Fereday, Sian, Hendley, Joy, Garsed, Dale W., Milne, Katy, Kalaria, Shreena, Marshall, Ashley, Hood, Brian L., Wilson, Katlin N., Conrads, Kelly A., Pishas, Kathleen I., Ananda, Sumitra, Scott, Clare L., Antill, Yoland, McNally, Orla, Mileshkin, Linda, Hamilton, Anne, Au-Yeung, George, Devereux, Lisa, Thorne, Heather, Bild, Andrea, Bateman, Nicholas W., Maxwell, G. Larry, Chang, Jeffrey T., Conrads, Thomas P., Nelson, Brad H., Bowtell, David D. L., Christie, Elizabeth L.

Issue&Volume: 2023-02-27

Abstract: High-grade serous ovarian cancer (HGSC) is frequently characterized by homologous recombination (HR) DNA repair deficiency and, while most such tumors are sensitive to initial treatment, acquired resistance is common. We undertook a multiomics approach to interrogate molecular diversity in end-stage disease, using multiple autopsy samples collected from 15women with HR-deficient HGSC. Patients had polyclonal disease, and several resistance mechanisms were identified within most patients, including reversion mutations and HR restoration by other means. We also observed frequent whole-genome duplication and global changes in immune composition with evidence of immune escape. This analysis highlights diverse evolutionary changes within HGSC that evade therapy and ultimately overwhelm individual patients.

DOI: 10.1038/s41588-023-01320-2

Source: https://www.nature.com/articles/s41588-023-01320-2

Nature Genetics：《自然—遗传学》，创刊于1992年。隶属于施普林格·自然出版集团，最新IF：41.307
官方网址：https://www.nature.com/ng/
投稿链接：https://mts-ng.nature.com/cgi-bin/main.plex