小柯机器人

华中农业大学李林等研究人员合作绘制出玉米的一个多组学综合网络图谱。相关论文于2022年12月29日在线发表在《自然—遗传学》杂志上。

Title: A multi-omics integrative network map of maize

Author: Han, Linqian, Zhong, Wanshun, Qian, Jia, Jin, Minliang, Tian, Peng, Zhu, Wanchao, Zhang, Hongwei, Sun, Yonghao, Feng, Jia-Wu, Liu, Xiangguo, Chen, Guo, Farid, Babar, Li, Ruonan, Xiong, Zimo, Tian, Zhihui, Li, Juan, Luo, Zi, Du, Dengxiang, Chen, Sijia, Jin, Qixiao, Li, Jiaxin, Li, Zhao, Liang, Yan, Jin, Xiaomeng, Peng, Yong, Zheng, Chang, Ye, Xinnan, Yin, Yuejia, Chen, Hong, Li, Weifu, Chen, Ling-Ling, Li, Qing, Yan, Jianbing, Yang, Fang, Li, Lin

Issue&Volume: 2022-12-29

Abstract: Networks are powerful tools to uncover functional roles of genes in phenotypic variation at a system-wide scale. Here, we constructed a maize network map that contains the genomic, transcriptomic, translatomic and proteomic networks across maize development. This map comprises over 2.8 million edges in more than 1,400 functional subnetworks, demonstrating an extensive network divergence of duplicated genes. We applied this map to identify factors regulating flowering time and identified 2,651 genes enriched in eight subnetworks. We validated the functions of 20 genes, including 18 with previously unknown connections to flowering time in maize. Furthermore, we uncovered a flowering pathway involving histone modification. The multi-omics integrative network map illustrates the principles of how molecular networks connect different types of genes and potential pathways to map a genome-wide functional landscape in maize, which should be applicable in a wide range of species.

DOI: 10.1038/s41588-022-01262-1

Source: https://www.nature.com/articles/s41588-022-01262-1

Nature Genetics：《自然—遗传学》，创刊于1992年。隶属于施普林格·自然出版集团，最新IF：41.307
官方网址：https://www.nature.com/ng/
投稿链接：https://mts-ng.nature.com/cgi-bin/main.plex