小柯机器人

华中农业大学Jianbing Yan，Ning Yang和美国加州大学戴维斯分校Jeffrey Ross-Ibarra共同合作，近期取得重要工作进展。他们通过基因组测序揭示了玉米属植物适应性变异的证据。相关论文2022年10月20日在线发表于《自然—遗传学》杂志上。

研究人员描述了一个高密度的基因组变异图谱，它来自744个基因组，包括玉米和玉米属的所有野生类群，确定了超过7000万个单核苷酸多态性。变异图谱揭示了在类群内显示新适应性的选择证据。研究人员重点关注高原茶树和温带玉米的适应性等位基因，强调花期相关途径在其适应中的关键作用。为了显示这些数据中变体的效用，研究人员为两个开花期候选基因生成突变等位基因。这项工作提供了玉米遗传多样性的广泛样本，解决了关于进化的问题，并确定了适应性变体，可直接用于现代育种。

据介绍，玉米是一种具有全球价值的商品，也是研究最广泛的遗传模式生物之一。然而，对在玉米野生近缘植物中发现遗传变异的程度和潜在用途却知之甚少。

附：英文原文

Title: Genome sequencing reveals evidence of adaptive variation in the genus Zea

Author: Chen, Lu, Luo, Jingyun, Jin, Minliang, Yang, Ning, Liu, Xiangguo, Peng, Yong, Li, Wenqiang, Phillips, Alyssa, Cameron, Brenda, Bernal, Julio S., Relln-lvarez, Rubn, Sawers, Ruairidh J. H., Liu, Qing, Yin, Yuejia, Ye, Xinnan, Yan, Jiali, Zhang, Qinghua, Zhang, Xiaoting, Wu, Shenshen, Gui, Songtao, Wei, Wenjie, Wang, Yuebin, Luo, Yun, Jiang, Chenglin, Deng, Min, Jin, Min, Jian, Liumei, Yu, Yanhui, Zhang, Maolin, Yang, Xiaohong, Hufford, Matthew B., Fernie, Alisdair R., Warburton, Marilyn L., Ross-Ibarra, Jeffrey, Yan, Jianbing

Issue&Volume: 2022-10-20

Abstract: Maize is a globally valuable commodity and one of the most extensively studied genetic model organisms. However, we know surprisingly little about the extent and potential utility of the genetic variation found in wild relatives of maize. Here, we characterize a high-density genomic variation map from 744 genomes encompassing maize and all wild taxa of the genus Zea, identifying over 70 million single-nucleotide polymorphisms. The variation map reveals evidence of selection within taxa displaying novel adaptations. We focus on adaptive alleles in highland teosinte and temperate maize, highlighting the key role of flowering-time-related pathways in their adaptation. To show the utility of variants in these data, we generate mutant alleles for two flowering-time candidate genes. This work provides an extensive sampling of the genetic diversity of Zea, resolving questions on evolution and identifying adaptive variants for direct use in modern breeding.

DOI: 10.1038/s41588-022-01184-y

Source: https://www.nature.com/articles/s41588-022-01184-y

Nature Genetics：《自然—遗传学》，创刊于1992年。隶属于施普林格·自然出版集团，最新IF：41.307
官方网址：https://www.nature.com/ng/
投稿链接：https://mts-ng.nature.com/cgi-bin/main.plex