小柯机器人

加拿大不列颠哥伦比亚大学Marco A. Marra研究团队通过对乌干达子宫颈癌的分析，确定了人类乳头瘤病毒进化枝特异性表观基因组和转录组图谱。这一研究成果于2020年8月3日在线发表在国际学术期刊《自然—遗传学》上。

研究人员鉴定了来自乌干达的118例肿瘤患者，其中72例是HIV+，并对另外89例肿瘤进行了扩展的突变分析。研究人员检测到人类乳头瘤病毒（HPV）进化枝特异性肿瘤DNA甲基化、启动子和增强子相关的组蛋白标记、基因表达以及通路失调。HPV整合事件中组蛋白修饰的变化与附近基因和内源性逆转录病毒的上调相关。

Author: Alessia Gagliardi, Vanessa L. Porter, Zusheng Zong, Reanne Bowlby, Emma Titmuss, Constance Namirembe, Nicholas B. Griner, Hilary Petrello, Jay Bowen, Simon K. Chan, Luka Culibrk, Teresa M. Darragh, Mark H. Stoler, Thomas C. Wright, Patee Gesuwan, Maureen A. Dyer, Yussanne Ma, Karen L. Mungall, Steven J. M. Jones, Carolyn Nakisige, Karen Novik, Jackson Orem, Martin Origa, Julie M. Gastier-Foster, Robert Yarchoan, Corey Casper, Gordon B. Mills, Janet S. Rader, Akinyemi I. Ojesina, Daniela S. Gerhard, Andrew J. Mungall, Marco A. Marra

Issue&Volume: 2020-08-03

Abstract: Cervical cancer is the most common cancer affecting sub-Saharan African women and is prevalent among HIV-positive (HIV+) individuals. No comprehensive profiling of cancer genomes, transcriptomes or epigenomes has been performed in this population thus far. We characterized 118 tumors from Ugandan patients, of whom 72 were HIV+, and performed extended mutation analysis on an additional 89 tumors. We detected human papillomavirus (HPV)-clade-specific differences in tumor DNA methylation, promoter- and enhancer-associated histone marks, gene expression and pathway dysregulation. Changes in histone modification at HPV integration events were correlated with upregulation of nearby genes and endogenous retroviruses. Genomic analysis of 118 cervical tumors from Ugandan individuals identifies HPV-clade-specific differences in tumor DNA methylation, regulatory-region-associated histone marks, gene expression and pathway dysregulation.

DOI: 10.1038/s41588-020-0673-7

Source: https://www.nature.com/articles/s41588-020-0673-7

Nature Genetics：《自然—遗传学》，创刊于1992年。隶属于施普林格·自然出版集团，最新IF：41.307
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投稿链接：https://mts-ng.nature.com/cgi-bin/main.plex