小柯机器人

谱系依赖性基因表达程序影响结直肠癌的免疫图谱
2020-05-27 14:37

韩国三星基因组研究所Woong-Yang Park和比利时鲁汶天主教大学Sabine Tejpar合作发现,谱系依赖性基因表达程序影响结直肠癌的免疫图谱。 这一研究成果于2020525日发表在《自然—遗传学》杂志上。

他们分析了来自23名韩国人和6名比利时人的91,103个未分类的单细胞的转录组。癌细胞显示出转录特征,使人联想到正常的分化程序和遗传改变,这些遗传改变显然促进了由调节性T细胞、成肌纤维细胞和髓样细胞定向的免疫抑制微环境。

细胞间网络重建支持癌细胞特征与特定基质或免疫细胞群之间的关联。他们对结直肠癌中细胞图谱和细胞间相互作用的总体观点,为有效的免疫肿瘤治疗策略设计提供了机理信息。

研究人员表示,转移性结直肠癌的免疫疗法仅对错配修复缺陷的、微卫星不稳定性较高的肿瘤有效,这些肿瘤表现出免疫浸润,表明肿瘤细胞可以确定其免疫微环境。

附:英文原文

Title: Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer

Author: Hae-Ock Lee, Yourae Hong, Hakki Emre Etlioglu, Yong Beom Cho, Valentina Pomella, Ben Van den Bosch, Jasper Vanhecke, Sara Verbandt, Hyekyung Hong, Jae-Woong Min, Nayoung Kim, Hye Hyeon Eum, Junbin Qian, Bram Boeckx, Diether Lambrechts, Petros Tsantoulis, Gert De Hertogh, Woosung Chung, Taeseob Lee, Minae An, Hyun-Tae Shin, Je-Gun Joung, Min-Hyeok Jung, Gunhwan Ko, Pratyaksha Wirapati, Seok Hyung Kim, Hee Cheol Kim, Seong Hyeon Yun, Iain Bee Huat Tan, Bobby Ranjan, Woo Yong Lee, Tae-You Kim, Jung Kyoon Choi, Young-Joon Kim, Shyam Prabhakar, Sabine Tejpar, Woong-Yang Park

Issue&Volume: 2020-05-25

Abstract: Immunotherapy for metastatic colorectal cancer is effective only for mismatch repair-deficient tumors with high microsatellite instability that demonstrate immune infiltration, suggesting that tumor cells can determine their immune microenvironment. To understand this cross-talk, we analyzed the transcriptome of 91,103 unsorted single cells from 23 Korean and 6 Belgian patients. Cancer cells displayed transcriptional features reminiscent of normal differentiation programs, and genetic alterations that apparently fostered immunosuppressive microenvironments directed by regulatory T cells, myofibroblasts and myeloid cells. Intercellular network reconstruction supported the association between cancer cell signatures and specific stromal or immune cell populations. Our collective view of the cellular landscape and intercellular interactions in colorectal cancer provide mechanistic information for the design of efficient immuno-oncology treatment strategies.

DOI: 10.1038/s41588-020-0636-z

Source: https://www.nature.com/articles/s41588-020-0636-z

Nature Genetics:《自然—遗传学》,创刊于1992年。隶属于施普林格·自然出版集团,最新IF:41.307
官方网址:https://www.nature.com/ng/
投稿链接:https://mts-ng.nature.com/cgi-bin/main.plex


本期文章:《自然—遗传学》:Online/在线发表

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