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Admixture Mapping Comes of Age
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Admixture Mapping Comes of Age*
Annual Review of Genomics and Human Genetics
https://wap.sciencenet.cn/blog-479743-548035.html
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Vol. 11: 65-89 (Volume publication date September 2010)
First published online as a Review in Advance on July 1, 2010
DOI: 10.1146/annurev-genom-082509-141523
Admixture mapping is based on the hypothesis that differences in disease rates between populations are due in part to frequency differences in disease-causing genetic variants. In admixed populations, these genetic variants occur more often on chromosome segments inherited from the ancestral population with the higher disease variant frequency. A genome scan for disease association requires only enough markers to identify the ancestral chromosome segments; for recently admixed populations, such as African Americans, 1,500–2,500 ancestry-informative markers (AIMs) are sufficient. The method was proposed over 50 years ago, but the AIM panels and statistical methods required have only recently become available. Since the first admixture scan in 2005, the genetic bases for a range of diseases/traits have been identified by admixture mapping. Here, we provide a historical perspective, review AIM panels and software packages, and discuss recent successes and unexpected insights into human diseases that exhibit disparate rates across human populations.
基本原理:利用混合群体进行关联作图.原理不同群体疾病发生率(某种性状发生的频率)部分归因于导致疾病(或研究性状)产生的遗传变异的频率的不同.
https://wap.sciencenet.cn/blog-479743-548035.html
上一篇：建立DH群体的新方法
下一篇：关于基因超表达的综述
