氢分子医学分享 http://blog.sciencenet.cn/u/孙学军 对氢气生物学效应感兴趣者。可合作研究:sunxjk@hotmail.com 微信 hydrogen_thinker

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氢气对抗透析致血液氧化损伤的临床研究

已有 4085 次阅读 2013-11-29 10:23 |个人分类:氢气医学临床|系统分类:论文交流

关于氢气的生物学效应研究,虽然研究论文非常多,而且发展速度也十分迅速,2007年全年只有3篇论文,而现在一年可以达到120多篇,可见氢气生物学研究的热度是很高的。氢气研究相对不足的是临床研究报道比较少,目前只有关于糖尿病方面相对比较多的临床研究论文(3篇),档次也比较高。另外,透析领域也有比较多的临床研究,到今天也已经有三篇研究论文,前两篇论文分别是研究将氢气加入透析液中对患者透析引起的血压低问题和氧化损伤具有保护作用,其中一篇是血液透析,另一篇是腹膜透析。

今天的研究是关于氢气对血液透析的研究,这个研究比较有意思,他们针对透析膜和血液接触引起的氧化损伤,其中一个研究是分别采集机器的采血端输入和输出端的患者血液,发现如果在透析液中溶液50ppb的氢气,可以明显减少透析过程导致的白蛋白氧化程度增加。这一研究尽管比较简单,但是非常直接的证明氢气对生物分子氧化损伤的对抗作用。而且这种过程是非常短暂,几乎可以肯定氢气存在直接的对抗氧化损伤的效应。虽然这一研究仍不能推延到其他氢气效应的分析,例如通过呼吸和喝氢气水的方法,但至少给我们提供了一个氢气具有直接抗氧化的证据。

该论文目前在线发表在

hdi12112.pdf

Hemodialysis International Article first published online: 26 NOV 2013

DOI: 10.1111/hdi.12112

Effect of a hydrogen(H2)-enriched solution on the albumin redox of hemodialysis patients

论文通讯作者为日本福岛医科大学血液透析中心的H. Terawaki博士。

Correspondence to: H. Terawaki,MD, PhD, Dialysis Center, Fukushima Medical University, 1 Hikariga-oka,Fukushima 960-1285, Japan. E-mail: terawaki@fmu.ac.jp

论文摘要

   Elevated oxidative stress (OS) isassociated with severe cardiovascular disease and premature death amongpatients treated with hemodialysis (HD). Oxidative stress is enhanced bycontact between blood and dialysis membranes during HD sessions. This studyaimed to clarify whether hydrogen (H2), which is a knownantioxidant, is capable of suppressing increased OS induced during HD sessions.Eight patients on regular HD treatment were studied. Two HD sessions wereperformed in a cross-over design trial using standard and hydrogen-enrichedsolutions (mean of 50 p.p.b. H2; H2-HD). Blood sampleswere obtained from the inlet and outlet of the dialyzer during HD to determinechanges in plasma levels of glutathione, hydrogen peroxide, and albumin redoxstate as a marker of OS. Comparison of inlet and outlet blood revealedsignificant decreases in total glutathione and reduced glutathione, as well assignificant increases in hydrogen peroxide in both HD treatments. However, themean proportion of reversibly oxidized albumin in outlet serum wassignificantly lower than that in inlet serum following the H2-HDsession, whereas no significant changes were found in the standard solutionsession, suggesting that “intra-dialyzer” OS is reduced by H2-HD. Inconclusion, the application of H2-enriched solutions couldameliorate OS during HD.




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