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诺奖文集 2018年诺贝尔医学奖 本庶佑

已有 1129 次阅读 2022-9-18 07:44 |个人分类:诺贝尔奖|系统分类:论文交流


Tasuku Honjo was born in Kyoto, Japan on January 27, 1942. He graduated from Kyoto University and is an immunologist. Winner of the 2018 Nobel Prize in Physiology or Medicine, foreign academician of the National Academy of Sciences, and member of the Japanese Academy of Sciences. He is now the Special Professor of the Institute of Higher Studies of Kyoto University, the Legal Director of Shizuoka Public University, and a cultural contributor.

In 1992, we discovered the T-cell inhibitory receptor PD-12, and in 2013, we pioneered cancer immunotherapy based on this. Our achievements ranked first in the annual top ten scientific breakthroughs of Science. At the same time, we are famous for the molecular identification of cytokines IL-4 and IL-5, and the discovery of activation induced cytidine deaminase (AID) that plays an important role in class transformation, recombination and somatic hypermutation.

Benshu is the winner of the "Koho Prize" of the Robert Koho Prize, the highest prize in German medicine, and is known as "one of the Japanese closest to the Nobel Prize". In 2014, he and James Allison jointly won the first Tang Prize for Biotechnology and Medicine [1]. On September 21, 2016, he was selected into the list of 2016 Citation Laureate Awards. On September 25, 2016, the second Tang Prize awarding ceremony was held grandly. Ben Shuyou, the winner of the first Tang Prize for Medical Sciences, won the prize [2]. In December 2016, it was awarded the first "Fudan Zhongzhi Science Award" [3]. On October 1, 2018, the 2018 Nobel Prize in Physiology or Medicine was announced, and James Allison and Ben Shuyou jointly won the prize, in recognition of their "contributions to the discovery of negative immunomodulation therapy for cancer".

本庶佑(Tasuku Honjo),1942年1月27日出生于日本京都府京都市,毕业于京都大学,免疫学家。2018年诺贝尔生理学或医学奖获得者,美国国家科学院外籍院士,日本学士院会员。现任京都大学高等研究院特别教授、静冈县公立大学法人理事长,文化功劳者。

本庶佑于1992年发现T细胞抑制受体PD-1,2013年依此开创了癌症免疫疗法,功绩名列《Science》年度十大科学突破之首。本庶同时因对细胞因子IL-4、IL5的分子鉴定,及发现对类转换重组及体细胞超变异具有重要作用的活化诱导胞苷脱氨酶(Activation-induced Cytidine Dearminase, AID)而知名。

本庶是德国医学最高奖罗伯·柯霍奖的“科霍奖”得主,被誉为“最接近诺贝尔奖的日本人之一”。2014年与詹姆斯·艾利森共同获得首届唐奖生技医药奖 [1]  。2016年9月21日,入选2016年引文桂冠奖名单。2016年9月25日,第二届唐奖颁奖典礼盛大举行,首届唐奖生医奖得主本庶佑获奖 [2]  。2016年12月,获颁首届“复旦-中植科学奖 [3]  。2018年10月1日,2018年诺贝尔生理学或医学奖揭晓,詹姆斯·艾利森和本庶佑共同获奖,以表彰他们“发现负性免疫调节治疗癌症的疗法方面的贡献”。


https://baike.baidu.com/item/%E6%9C%AC%E5%BA%B6%E4%BD%91/15826826?fromModule=lemma_inlink



https://pubmed.ncbi.nlm.nih.gov/19234458/


https://pubmed.ncbi.nlm.nih.gov/?term=Honjo+T&cauthor_id=19234458


summary-HonjoT-set.txt



http://www.pubmedplus.cn/P/SearchQuickResult?wd=75d770b7-c510-4257-a2b4-92b834e8319e


01.无法确认1 篇0.125%
02.20224 篇0.499%
03.202115 篇1.873%
04.202012 篇1.498%
05.20195 篇0.624%
06.20189 篇1.124%
07.201711 篇1.373%
08.20169 篇1.124%
09.201513 篇1.623%
10.201415 篇1.873%
11.201314 篇1.748%
12.201213 篇1.623%
13.201120 篇2.497%
14.201014 篇1.748%
15.200926 篇3.246%
16.200822 篇2.747%
17.200729 篇3.620%
18.200625 篇3.121%
19.200523 篇2.871%
20.200423 篇2.871%
21.200328 篇3.496%
22.200230 篇3.745%
23.200128 篇3.496%
24.200023 篇2.871%
25.199923 篇2.871%
26.199818 篇2.247%
27.199723 篇2.871%
28.199618 篇2.247%
29.199512 篇1.498%
30.199416 篇1.998%
31.199317 篇2.122%
32.199213 篇1.623%
33.199120 篇2.497%
34.199017 篇2.122%
35.198922 篇2.747%
36.198830 篇3.745%
37.198723 篇2.871%
38.198618 篇2.247%
39.198518 篇2.247%
40.198417 篇2.122%
41.19839 篇1.124%
42.198216 篇1.998%
43.19818 篇0.999%
44.198011 篇1.373%
45.19793 篇0.375%
46.19783 篇0.375%
47.19773 篇0.375%
48.19762 篇0.250%
49.19751 篇0.125%
50.19743 篇0.375%
51.19732 篇0.250%
52.19711 篇0.125%
53.19703 篇0.375%
54.19692 篇0.250%
55.19685 篇0.624%
56.19673 篇0.375%
57.19663 篇0.375%
58.19652 篇0.250%
59.19644 篇0.499%
01.proc natl acad sci u s a77 篇9.613%
02.j exp med39 篇4.869%
03.int immunol34 篇4.245%
04.j biol chem30 篇3.745%
05.j immunol26 篇3.246%
06.nucleic acids res25 篇3.121%
07.nature23 篇2.871%
08.immunol lett17 篇2.122%
09.embo j14 篇1.748%
10.nat immunol14 篇1.748%
01.日本571 篇71.286%
02.美国50 篇6.242%
03.法国6 篇0.749%
04.瑞士6 篇0.749%
05.中国4 篇0.499%
06.澳大利亚3 篇0.375%
07.德国3 篇0.375%
08.加拿大3 篇0.375%
09.英国3 篇0.375%
10.瑞典2 篇0.250%
01.中国上海1 篇0.125%
02.中国西安1 篇0.125%
01.Animals555 篇69.288%
02.Mice410 篇51.186%
03.Humans326 篇40.699%
04.Base Sequence179 篇22.347%
05.B-Lymphocytes131 篇16.355%
06.Male127 篇15.855%
07.Molecular Sequence Data125 篇15.605%
08.Cell Line122 篇15.231%
09.Female120 篇14.981%
10.DNA101 篇12.609%






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