血液循环在大脑信息处理过程中的时序控制作用整理.pdf

【摘要】 本文针对《大脑处理信息的过程存储与重组模型》和《血液循环在大脑处理信息过程中的时序控制作用》发表
后，一些同行反馈较难理解的问题，对已发表的文献[1-5]从以下四个方面进行解析，以期同行对其有更深入的理解。（一）总结前面提出血液循环在大脑信息处理过程中有时序控制作用的主要依据有如下几点： ① 因为毛细血管供血半径可以精确到和锥体细胞体积一致，所以血液循环有可能在精确到细胞的空间精度上造成所带来物质的浓度差，从而对不同信息处理组织起不同的子网络；② 血管在秒的时间尺度内相对定型的和微循环系统的调节机制，这保证了一定的子网络结构稳定性和子网络组织灵活性；③ 浓度差异可以随血液灌注到达而发生，这涉及到物质的运输速度问题，一些物质的运输速度可以达到这个要求，例如O2和CO2；④ 已经发生的浓度差异需要有能够影响信息处理的分子机制基础：这是存在的，例如PH值波动对NMDA受体活性的影响；O2的不同造成糖不同方式代谢量比例的不同，进而影响ATP产量；⑤ 血液循环对信息处理在秒或者更小时间尺度上的影响可以观察到，大脑血行停止5-10秒后可以引起意识的消失，这个时间同微动脉和毛细血管自律周期时间尺度相近；⑥ 所运输到达的物质是化学反应网络中的瓶颈物质，例如O2；⑦ 综合分析各种情况下的脑电图现象。（二）简要介绍所建立的脑电波模型；（三）总结人工神经网络研究规律，用结构风险最小化等工具分析了血液循环的时序控制作用在大脑高效率处理信息方面的意义，说明语言机制，海马结构等因为相同的原因有利于大脑高效率处理信息；（四）介绍过程存储与重组模型的一些观点和作用。
【关键词】过程存储与重组模型  脑电波  血液循环  时序控制  结构风险最小化  时间认知  微循环

 

A Review of <Timer Role of Blood Circulation When Brain Processing information>
【Abstract】 After publish of < Storing and Re-engineering of Models of Cerebral Information Process >and  
<Timer Role of Blood Circulation when Brain Processing Information>, some peers fed back that those papers are hard to understand. In order to make the theory easier to be understood, this paper gives a brief review of [1-5], including four parts. Part 1 gives a brief review of evidences that support blood circulation has timing control function when brain processing information: (1) Because the diameters of capillaries can be smaller than a pyramid cell, artery blood can engender concentration differences of matters brought by itself in a spatial precision of a single cell. (2)Because blood vessels can relatively maintain their modal stability in a time scale of second, the sub networks that formed by microcirculation mechanism when processing different information have relative stability and changeability. (3)Transport speeds of some matters (e.g. O2, CO2) from capillaries to tissue (or from tissue to capillaries) are quick enough, so that concentration differences of these matters can be engendered as soon as artery blood arrives. (4)Concentration differences that have been engendered are able to effect information processing. For example, H+ can depress NMDA receptors; O2 effects the production of ATP. (5) One will lost conscious 5-10 seconds after stop of blood supply, this time scale is same with active periods of micro arteries and capillaries.(6)Some
matters brought by artery blood are ‘bottle neck matters’ of biochemical reactions, e.g. O2.(7)EEG phenomena that are mentioned in the EEG model we have built. Part 2 gives a brief review of the EEG model that we have
built. With the help of some math tools from artificial intelligence area (e.g. Structure risk minimization etc.), Part 3 explains why timing control function of blood circulation is important when brain processing information efficiently; and explains why physiology structures and mechanisms that are able to organize respective sub networks (e.g. language mechanism, hippocampus formation etc.) when brain processing different information are important when brain processing information efficiently. Part 4 introduces some viewpoints of “model of process storing and recalling”.
【Key words】model of process storing and recalling  EEG  blood circulation  timing control  Structure risk
minimization  time cognition  information process  CNS  micro circulation