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摄硒能抗癌吗?

已有 5935 次阅读 2011-5-12 11:08 |个人分类:分享|系统分类:论文交流| 生物学, 临床试验, 学术界, 前列腺癌, 皮肤癌

     关于硒元素(Selenium,Se)的生物学效应,研究得最多的恐怕是其抗癌作用,但学术界对此历来就存有争议[1-15]

 

     尽管如此,人们还是相信摄硒能够降低癌症风险。许多食物中都富含硒,如巴西坚果(brazil nuts,如下图)。然而,最近的一项随机控制临床试验(RCCT,randomized controlled clinical trials)研究表明,硒对非黑素类的皮肤癌、前列腺癌都无防范作用。研究结果发表在Cochrane Database Syst. Rev(2011年,第5期,DOI: 10.1002/14651858.CD005195)上。主持这项研究的是来自德国柏林THR学院(Institute for Transdisciplinary Health Research)的Gabriele Dennert 教授。

     该研究组搜索了摄硒效应的临床研究文献,发现了49项预期的观察研究(observational studies)和6项随机控制临床试验。其中,观察研究表明,高硒摄入可以防范癌症,但RCCT研究却表明无此明显作用。另外还有迹象表明,如果摄硒时程过长,会造成有害效应。  

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