宝子们，今天来给大家科普一个最近的科研发现。近年来超火的新型二维材料——黑磷（BP），在光电、生物和医学领域那可是潜力无限，但它也可能悄悄给环境和健康带来风险。科学家们用野生型和转基因斑马鱼做了实验，研究小尺寸黑磷（S - BP）在较低浓度下的影响。结果真的让人捏把汗。S - BP会附着在斑马鱼卵膜上，让幼体发育出问题。120小时后，幼体的鳔充不了气，心率还下降了。72小时时，血管发育就受到影响，特别是总主静脉（CCV）。而且120小时后，红细胞生成和流速也不正常了。转录组分析还发现，S - BP会改变好多和血管生成、造血相关的基因表达，一些重要标志物的mRNA水平都明显降低。这说明低浓度的S - BP就会造成血管和血液毒性，CCV和红细胞特别容易受影响。这也给我们提了个醒，新材料虽然好，但环境和健康风险不能忽视呀。
期刊
Environmental Science & Technology
标题
Small Black Phosphorus Disrupts Vascular Development and Hematopoiesis in Zebrafish Larvae
作者
Zhuyi Zhang, Hua Chang, Yu Hao, Zikang Li, Hua Qin, Xinyi Yu, Jiaorong Li, Mengxi Cao, Ling Wang, Yong Liang, Li Cai, Runzeng Liu, Xiaoxi Yang, Yanhong Wei, Guibin Jiang
摘要
Black phosphorus (BP), a novel two-dimensional (2D) material, has shown promising applications in the optoelectronic, biological, and medical fields in recent years. However, its increasing use may lead to its inadvertent environmental release, creating potential ecological and health risks that remain poorly understood. In this study, wild-type and transgenic zebrafish were used to evaluate the potential developmental toxicity of small-size BP (S-BP), with a lateral particle size of 154.4 ± 34.6 nm, focusing specifically on vascular growth and hematopoiesis at relatively low concentrations of 0.025, 0.05, 0.1, and 0.2 mg/L. The results indicated that S-BP adhered to the chorion and induced developmental defects. The uninflated swim bladders and decreased heart rate were observed in S-BP-exposed larvae at 120 hpf. The angioarchitectural profiling using transgenic zebrafish showed that exposure to S-BP adversely impaired blood vessel development at 72 hpf, especially in the common cardinal vein (CCV). Moreover, erythropoiesis and the flow velocity of red blood cells (RBCs) were disturbed at 120 hpf in all of the S-BP-exposed groups. Transcriptomic analysis unveiled that S-BP exposure altered gene expression related to angiogenesis, hematopoiesis, ribosome function, and transport processes. Notably, the mRNA levels of vascular and hematopoietic markers, including clec14a, nme2b.1, klf2a, slc2a1a, csf1rb, atf3, scl, and scml4, were significantly downregulated following S-BP exposure. Our findings revealed that low concentrations of S-BP exposure caused vascular and hematologic toxicity and identified CCV and RBCs as sensitive targets. This work expands our understanding of the toxicity of 2D nanomaterials and provides critical data for environmental risk assessment.
原文链接
https://pubs.acs.org/doi/10.1021/acs.est.4c14490
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静远嘲风（MY Scimage） 成立于2007年，嘲风取自中国传统文化中龙生九子，子子不同的传说，嘲风为守护屋脊之瑞兽，喜登高望远；静远取自成语“宁静致远”，登高莫忘初心，远观而不可务远。
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