宝子们，今天来和大家聊聊铅这个环境污染物对大脑的影响😱。铅对神经发育的影响可是非常持久的，而且儿童比成年人对铅暴露更敏感，尤其是胎儿期的铅暴露，会伤害胎儿的神经系统。最近有一项很厉害的研究，科学家让小鼠在产前和产后都暴露于铅环境中，然后用单细胞核RNA测序技术去分析2周龄和8周龄小鼠的大脑🧠。这里有个超重要的点，暴露小鼠的血铅水平和人类样本中的差不多，说明这个研究对我们人类也有参考价值呢。他们一共分析了43303个脑细胞，有超惊人的发现。在2周龄小鼠大脑里，铅让未成熟神经元比例增加，还干扰了神经发育和神经结构相关的通路。8周龄小鼠呢，铅主要影响突触传递、信号转导、学习记忆这些通路。更关键的是，神经元和小胶质细胞之间有关神经递质谷氨酸和γ - 氨基丁酸（GABA）的通讯也被破坏。原来铅诱导的神经毒性有细胞异质性，小胶质细胞和神经元之间神经递质通讯的破坏可能是铅致神经毒性的关键。这个研究真的让我们对铅暴露对大脑的影响有了新认识。宝子们一定要重视起来，尽量远离铅污染哦。
期刊
Environmental Science & Technology
标题
Single-Nucleus Transcriptomics Reveals Prenatal and Postnatal Pb Exposure-Induced Cell-Specific Neurotoxicity and Dysregulated Microglia-Neuron Communication in Mice Brain
作者
Xuting Liu, Chunfeng Huang, Mingyue Wang, Ligang Hu, Yang Song, Guibin Jiang
摘要
Lead (Pb) is an environmental pollutant that has lasting effects on neurodevelopment. Children exhibit heightened sensitivity to Pb exposure compared to adults, and prenatal Pb exposure can harm the developing fetal nervous system. However, the specific regulatory effects of Pb across various developmental stages are not well understood. This study employed single-nucleus RNA sequencing (snRNA-seq) to analyze mice brains at different ages (2 and 8 weeks) following prenatal and postnatal Pb exposure. Blood lead level in exposed mice is comparable to those detected in human samples, implying its environmental implication. A total of 43,303 brain cells were sequenced for cell-specific analysis. Pb exposure was found to elevate the proportion of immature neurons in the brains of 2 week-old mice and to perturb neurodevelopment- and neural structure-related pathways within neurons. In 8 week-old mice, Pb primarily influenced pathways implicated in synaptic transmission, signal transduction, and learning and memory in both neurons and glial cells. The communication involving neurotransmitters glutamate and γ-aminobutyric acid (GABA), along with their receptors, was disrupted between neuron
原文链接
https://pubs.acs.org/doi/10.1021/acs.est.5c00613
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静远嘲风（MY Scimage） 成立于2007年，嘲风取自中国传统文化中龙生九子，子子不同的传说，嘲风为守护屋脊之瑞兽，喜登高望远；静远取自成语“宁静致远”，登高莫忘初心，远观而不可务远。
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