科学网-云师大化工学院叶龙武教授团队朱欣祺研究员等在Angew. Chem. Int. Ed. （德国应化）上发表最新成果-蒋金和的博文

云师大化工学院叶龙武教授团队朱欣祺研究员等在Angew. Chem. Int. Ed. （德国应化）上发表最新成果

2025-8-7 10:32

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2025年8月5日，Wiley旗下知名期刊《Angewandte Chemie International Edition》在线发表了云南师范大学化学化工学院高层次柔性引进人才、厦门大学化学化工学院教授叶龙武教授团队与云南师范大学高端引进人才朱欣祺和浙江大学可持续能源研究院洪鑫教授等团队合作的最新研究成果《Copper-Catalyzed Asymmetric [2 + 2 + 2] Cycloaddition of Diynes via Vinyl Cations》.云南师范大学化学化工学院高层次柔性引进人才、厦门大学化学化工学院教授叶龙武教授、云南师范大学化学化工学院高层次引进人才、朱欣祺研究员和浙江大学可持续能源研究院洪鑫教授为共同通讯作者。第一作者单位为厦门大学化学化工学院。

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Abstract

Catalytic asymmetric [2 + 2 + 2] cycloaddition of diynes represents an efficient and atom-economical strategy for the assembly of valuable chiral cyclic targets in a single step. However, this strategy traditionally relies on the cyclometallation process. Moreover, there are no versatile asymmetric [2 + 2 + 2] cycloaddition methods for diynes that are compatible with C─C double/triple bonds and C─X double bonds. Here, we disclose a copper-catalyzed asymmetric [2 + 2 + 2] cycloaddition of diynes via vinyl cations. This universal [2 + 2 + 2] cycloaddition is suitable for the asymmetric cycloaddition of diynes with various C─C double/triple bonds and C─X double bonds, leading to a range of valuable chiral hexahydropyrrolocarbazoles, tetrahydropyrrolocarbazoles, and tetrahydropyran[4,3-b]indoles in generally excellent yields with excellent diastereo- and enantioselectivities. Importantly, this protocol features the first asymmetric [2 + 2 + 2] cycloaddition via vinyl cations, and constitutes the first construction of carbon stereocenters in triyne cyclization.

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