2025年诺贝尔生理学或医学奖授予了Mary E. Brunkow、Fred Ramsdell和Shimon Sakaguchi三位科学家，以表彰他们在外周免疫耐受机制领域的突破性发现。他们的研究揭示了免疫系统如何避免攻击自身组织，证实了除胸腺内的“中枢筛选”外，机体还存在着一套精密的“外周免疫耐受”机制。这些发现不仅颠覆了传统认知，开创了免疫学全新领域，更推动了癌症、自身免疫疾病及器官移植治疗的创新策略开发。您还在为筛选外周免疫相关文献而发愁吗？Biomedicines 期刊这份“外周免疫耐受”方向的文献清单，定能为你提供灵感！

1.The Role of Tregs in the Tumor Microenvironment

调节性T细胞在肿瘤微环境中的作用

https://www.mdpi.com/2227-9059/13/5/1173

2.Rapamycin Treatment Alleviates Chronic GVHD-Induced Lupus Nephritis in Mice by Recovering IL-2 Production and Regulatory T Cells While Inhibiting Effector T Cells Activation

雷帕霉素治疗可通过恢复IL-2生成及调节性T细胞功能，并抑制效应T细胞的活化，从而缓解慢性移植物抗宿主病（GVHD）诱发的小鼠狼疮性肾炎

https://www.mdpi.com/2227-9059/11/3/949

3.Opposite Effects of mRNA-Based and Adenovirus-Vectored SARS-CoV-2 Vaccines on Regulatory T Cells: A Pilot Study

信使RNA与腺病毒载体SARS-CoV-2疫苗对调节性T细胞产生相反作用：一项初步研究

https://www.mdpi.com/2227-9059/11/2/511

4.The Abundance of FOXP3, FOXP3/CD4 and CD8 Cells in the Microenvironment of Nodular Sclerosis and Mixed Cellularity Subtypes Is Associated with the Epstein–Barr Virus Status of Classic Hodgkin Lymphoma

结节硬化型和混合细胞型经典霍奇金淋巴瘤微环境中FOXP3、FOXP3/CD4和CD8细胞丰度与Epstein-Barr病毒感染状态相关

https://www.mdpi.com/2227-9059/12/8/1680

5.An Immunomodulating Peptide with Potential to Promote Anticancer Immunity Without Compromising Immune Tolerance

一种可促抗癌免疫且不损免疫耐受的免疫调节肽

http://www.mdpi.com/2227-9059/13/8/1908

6.Legend or Truth: Mature CD4+CD8+ Double-Positive T Cells in the Periphery in Health and Disease

谜团与真相：生理与病理状态下的外周成熟CD4+CD8+双阳性T细胞

https://www.mdpi.com/2227-9059/11/10/2702

7.Pituitary–Adrenal Axis and Peripheral Immune Cell Profile in Long COVID

长新冠的垂体-肾上腺轴和外周免疫细胞图谱

https://www.mdpi.com/2227-9059/12/3/581

8.Advanced Immunomodulation in Rheumatoid Arthritis: Immune Checkpoints, microRNAs, and Cell-Based Therapies

类风湿性关节炎的高级免疫调节：免疫检查点，microRNAs和细胞疗法

https://www.mdpi.com/2227-9059/13/9/2186

9.Construction of Diagnostic Model for Regulatory T Cell-Related Genes in Sepsis Based on Machine Learning

基于机器学习的脓毒症调节性T细胞相关基因诊断模型构建

https://www.mdpi.com/2227-9059/13/5/1060

10.Vagus Nerve Stimulation Regulates the Th17/Treg Balance and Alleviates Lung Injury in Acute Respiratory Distress Syndrome by Upregulating α7nAChR

迷走神经刺激通过上调α7nAChR调节Th17/Treg平衡，和减轻急性呼吸窘迫综合征的肺损伤

https://www.mdpi.com/2227-9059/13/6/1294

11.Increased STAT3 Phosphorylation in CD4+ T-Cells of Treated Patients with Chronic Lymphocytic Leukemia and Changes in Circulating Regulatory T-Cell Subsets Relative to Tumor Mass Distribution Value and Disease Duration

慢性淋巴细胞白血病患者CD4+ T细胞STAT3磷酸化水平增加及循环调节性T细胞亚群与肿瘤质量分布值和病程相关的变化

https://www.mdpi.com/2227-9059/13/5/1204

12.ABCC1, ABCG2 and FOXP3: Predictive Biomarkers of Toxicity from Methotrexate Treatment in Patients Diagnosed with Moderate-to-Severe Psoriasis

ABCC1、ABCG2和FOXP3：预测中度至重度银屑病患者甲氨蝶呤治疗毒性的生物标志物

https://www.mdpi.com/2227-9059/11/9/2567

13.Exploring the Regulatory Role of XIST-microRNAs/mRNA Network in Circulating CD4+ T Cells of Hepatocellular Carcinoma Patients

XIST-microRNAs/mRNA网络在肝癌患者循环CD4+ T细胞中调控作用的探索

https://www.mdpi.com/2227-9059/11/7/1848

14.CBP/P300 Inhibition Impairs CD4+ T Cell Activation: Implications for Autoimmune Disorders

CBP/P300抑制损害CD4+ T细胞活化：对自身免疫性疾病的启示

https://www.mdpi.com/2227-9059/12/6/1344

15.PPARgamma Modulates CD4+ T-Cell Differentiation and Allergic Inflammation in Allergic Rhinitis: A Potential Therapeutic Target

PPARgamma调节过敏性鼻炎的CD4+ T细胞分化和过敏性炎症：一个潜在的治疗靶点

https://www.mdpi.com/2227-9059/13/7/1616

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