特刊（Special Issue）聚焦于期刊发稿范围中某一专题研究领域的一系列研究文章，通常围绕一个特别新的主题，一个新兴的领域，或一个现有研究问题的新视角。

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征稿特刊

新兴细胞死亡在炎症及肿瘤微环境的作用

Emerging Cell Death in Inflammation and Tumor Microenvironment

特刊简介：

本特刊重点探讨炎症与肿瘤微环境（TME）的复杂关系，聚焦新兴细胞死亡机制（如铁死亡、铜死亡、泛凋亡）的双重作用。慢性炎症通过破坏免疫平衡、促进基因组不稳定，形成促癌微环境；而TME中的免疫失调（如抑制杀伤性T细胞、招募促瘤免疫细胞）则助长肿瘤生长和转移。研究发现，新型细胞死亡方式既能通过清除癌细胞抑制肿瘤，也可能通过释放炎症信号间接促进肿瘤进展。例如铁死亡既可杀伤肿瘤细胞，其释放的损伤分子也可能加剧炎症；泛凋亡则能通过整合多种死亡途径动态调控免疫反应。未来研究需深入解析这些机制的关键调控基因与通路，以开发靶向调节细胞死亡的新型疗法，从而增强抗肿瘤免疫并控制炎症相关疾病。

此特刊聚焦以下关键主题：

• Molecular mechanisms underlying emerging modes of cell death (e.g. Ferroptosis, Cuproptosis, PANoptosis, etc.)

• The role of crosstalk between emerging cell death mechanisms and inflammatory diseases such as inflammatory bowel disease (IBD), bronchitis, arthritis

• Common impacts of emerging cell death mechanisms on inflammation and tumorigenesis

• The complex effects of emerging cell death pathways on the immune microenvironment, including how regulated death of various immune cells influences tumor biology

• Investigations into crosstalk effects among these emerging forms of cell death during tumor progression and therapy

• An examination of the role played by these processes in inflammatory diseases along with their associated signaling pathways

• Identification of genes, signaling molecules, and pathways regulating these emerging cell deaths and their interplay with inflammation

• The potential for new drugs and nanoparticles to affect emerging regulated cell death (RCD) pathways, and their therapeutic implications for cancer

• The impact of modulating RCD pathways on drug resistance within cancer therapies

客座主编：

Xudong Qu，Zhongshan Hospital, Fudan University, Shanghai, China

客座编辑：

1Hua Zhu，Peking University Cancer Hospital, Beijing, China

2Hengrui Liu，University of Cambridge, Cambridge, UK

3Bufu Tang，Zhejiang University, Hangzhou, China

投稿须知：

您可任意选择期刊，通过点击各期刊特刊主页上的投稿链接进行投稿。并在投稿系统中有关”Special Issue”的下拉菜单中选择此特刊主题

本期特刊截稿日期：

2025年8月22日

期刊简介：

Mediators of Inflammation is an open access journal that publishes papers on all types of inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, leukotrienes, PAF, biological response modifiers and the family of cell adhesion-promoting molecules.

Citation Impact

扫码查看Mediators of Inflammation的特刊主页：

https://onlinelibrary.wiley.com/doi/toc/10.1155/4792.si.622303

期刊简介：

Journal of Immunology Research is an open access journal that provides a platform for scientists and clinicians working in different and diverse areas of immunology and therapy.

Citation Impact

扫码查看Journal of Immunology Research的特刊主页：

https://onlinelibrary.wiley.com/doi/toc/10.1155/1607.si.268161

期刊简介：

International Journal of Inflammation is an open access journal that publishes papers on the molecular basis, cell biology and pharmacology of inflammation, including acute/chronic inflammation and the cellular processes/molecular mechanisms involved in inflammatory responses.

Citation Impact

扫码查看International Journal of Inflammation的特刊主页：

https://onlinelibrary.wiley.com/doi/toc/10.1155/8519.si.354673

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