小柯机器人

英国牛津大学Ana I. L. Namburete等研究人员绘制出标准的胎儿脑成熟数字图谱。该项研究成果于2023年10月25日在线发表在《自然》杂志上。

研究人员根据世界卫生组织推荐的生长标准，对健康孕妇进行了前瞻性的国际队列筛选，并在此基础上绘制了胎儿大脑成熟的标准数字图谱。她们的胎儿在妊娠头三个月的日期准确，从妊娠早期到2岁的生长和神经发育均令人满意。该图谱使用了来自899个胎儿的1059个最佳质量的三维超声脑容积和一个自动分析管道。该图谱在结构上与已发表的磁共振图像相对应，但深部灰质的解剖细节更为精细。研究地点之间的差异在所有脑部测量的总差异中所占比例不到8.0%，这支持将八个研究地点的数据汇集在一起，得出正常成熟度的模式。

因此，研究人员得出了妊娠14至31周期间每个大脑半球的平均值，并对颅内容积变异和生长模式进行了量化。早在妊娠14周时，研究人员就发现了新出现的不对称现象，而在妊娠20至26周期间，与语言发育和功能侧化相关的区域的不对称现象达到了顶峰。这些模式在同一队列中来自1295个不同胎儿的1487个三维脑体积中得到了验证。研究人员从一个具有正常产后生长和神经发育的大型队列中，为胎儿大脑成熟提供了一个独特的时空基准。

据了解，人类胎儿大脑的成熟应精确地遵循预定的大脑皮层结构生长和折叠，以实现最佳的产后功能。

附：英文原文

Title: Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years

Author: Namburete, Ana I. L., Papie, Bartomiej W., Fernandes, Michelle, Wyburd, Madeleine K., Hesse, Linde S., Moser, Felipe A., Ismail, Leila Cheikh, Gunier, Robert B., Squier, Waney, Ohuma, Eric O., Carvalho, Maria, Jaffer, Yasmin, Gravett, Michael, Wu, Qingqing, Lambert, Ann, Winsey, Adele, Restrepo-Mndez, Mara C., Bertino, Enrico, Purwar, Manorama, Barros, Fernando C., Stein, Alan, Noble, J. Alison, Molnr, Zoltn, Jenkinson, Mark, Bhutta, Zulfiqar A., Papageorghiou, Aris T., Villar, Jos, Kennedy, Stephen H.

Issue&Volume: 2023-10-25

Abstract: Maturation of the human fetal brain should follow precisely scheduled structural growth and folding of the cerebral cortex for optimal postnatal function1. We present a normative digital atlas of fetal brain maturation based on a prospective international cohort of healthy pregnant women2, selected using World Health Organization recommendations for growth standards3. Their fetuses were accurately dated in the first trimester, with satisfactory growth and neurodevelopment from early pregnancy to 2years of age4,5. The atlas was produced using 1,059 optimal quality, three-dimensional ultrasound brain volumes from 899 of the fetuses and an automated analysis pipeline6,7,8. The atlas corresponds structurally to published magnetic resonance images9, but with finer anatomical details in deep grey matter. The between-study site variability represented less than 8.0% of the total variance of all brain measures, supporting pooling data from the eight study sites to produce patterns of normative maturation. We have thereby generated an average representation of each cerebral hemisphere between 14 and 31weeks’ gestation with quantification of intracranial volume variability and growth patterns. Emergent asymmetries were detectable from as early as 14weeks, with peak asymmetries in regions associated with language development and functional lateralization between 20 and 26weeks’ gestation. These patterns were validated in 1,487 three-dimensional brain volumes from 1,295 different fetuses in the same cohort. We provide a unique spatiotemporal benchmark of fetal brain maturation from a large cohort with normative postnatal growth and neurodevelopment.

DOI: 10.1038/s41586-023-06630-3

Source: https://www.nature.com/articles/s41586-023-06630-3

Nature：《自然》，创刊于1869年。隶属于施普林格·自然出版集团，最新IF：69.504
官方网址：http://www.nature.com/
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