瑞士联邦理工学院Friedhelm C. Hummel研究组的研究表明，对人体纹状体进行无创θ-脉冲刺激可增强纹状体活动和运动技能学习能力。2023年10月19日出版的《自然-神经科学》杂志发表了这项成果。
研究人员通过计算建模、磁共振成像功能研究和行为评估，成功验证了经颅电刺激（tTIS）能对人纹状体进行非侵入性神经调节。θ-脉冲纹状体tTIS增加了纹状体和相关运动网络的活动。
此外，纹状体tTIS还能提高运动能力，尤其是健康的老年参与者，因为他们的自然学习能力低于年轻的受试者。这些研究结果证明tTIS是一种潜在的新方法，可以无创方式靶向人类大脑深层结构，从而加深人们对其功能作用的了解。
此外，该研究结果还为针对脑部疾病的创新无创治疗方法奠定了基础，因为在脑部疾病中，深层纹状体结构发挥关键的病理生理作用。
据悉，目前只有侵入性方法才能刺激大脑深层结构。tTIS是一种新型非侵入刺激技术，其有可能克服这一限制。
附：英文原文
Title: Noninvasive theta-burst stimulation of the human striatum enhances striatal activity and motor skill learning
Author: Wessel, Maximilian J., Beanato, Elena, Popa, Traian, Windel, Fabienne, Vassiliadis, Pierre, Menoud, Pauline, Beliaeva, Valeriia, Violante, Ines R., Abderrahmane, Hedjoudje, Dzialecka, Patrycja, Park, Chang-Hyun, Maceira-Elvira, Pablo, Morishita, Takuya, Cassara, Antonino M., Steiner, Melanie, Grossman, Nir, Neufeld, Esra, Hummel, Friedhelm C.
Issue&Volume: 2023-10-19
Abstract: The stimulation of deep brain structures has thus far only been possible with invasive methods. Transcranial electrical temporal interference stimulation (tTIS) is a novel, noninvasive technology that might overcome this limitation. The initial proof-of-concept was obtained through modeling, physics experiments and rodent models. Here we show successful noninvasive neuromodulation of the striatum via tTIS in humans using computational modeling, functional magnetic resonance imaging studies and behavioral evaluations. Theta-burst patterned striatal tTIS increased activity in the striatum and associated motor network. Furthermore, striatal tTIS enhanced motor performance, especially in healthy older participants as they have lower natural learning skills than younger subjects. These findings place tTIS as an exciting new method to target deep brain structures in humans noninvasively, thus enhancing our understanding of their functional role. Moreover, our results lay the groundwork for innovative, noninvasive treatment strategies for brain disorders in which deep striatal structures play key pathophysiological roles.
DOI: 10.1038/s41593-023-01457-7
Source: https://www.nature.com/articles/s41593-023-01457-7
Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex
本期文章：《自然—神经科学》：Online/在线发表
