小柯机器人

上海纽约大学脑与认知科学联合研究中心Jeffrey C. Erlich小组的研究发现，大鼠额叶定向场动态调控风险情形下经济决策的价值。相关论文于2023年10月19日发表在《自然-神经科学》杂志上。

当大鼠在不确定金额彩票和小额稳定的确定投注之间进行选择时，研究人员对额叶定向场（FOF）和后顶叶皮层（PPC）进行了沉默。PPC失活产生的短暂效应微乎其微。FOF失活会明显减少彩票选择。选择混合代理模型表明，沉默FOF会导致大鼠效用函数（U = Vρ）的曲率发生变化。与这一发现相一致的是，对单个神经元和群体神经活动的分析证实，FOF编码了每次试验的彩票价值。

一个能解释电生理和沉默结果的动力学模型表明，FOF代表了当前的彩票值，用于与记忆中的确定投注值进行比较。这些结果表明，FOF是神经回路中的关键节点，用于动态风险下选择的行动值。

据悉，额叶和顶叶皮层与经济决策有关，但它们与经济决策之间的因果关系尚未得到验证。

附：英文原文

Title: The rat frontal orienting field dynamically encodes value for economic decisions under risk

Author: Bao, Chaofei, Zhu, Xiaoyue, Mller-Mara, Joshua, Li, Jingjie, Dubroqua, Sylvain, Erlich, Jeffrey C.

Issue&Volume: 2023-10-19

Abstract: Frontal and parietal cortex are implicated in economic decision-making, but their causal roles are untested. Here we silenced the frontal orienting field (FOF) and posterior parietal cortex (PPC) while rats chose between a cued lottery and a small stable surebet. PPC inactivations produced minimal short-lived effects. FOF inactivations reliably reduced lottery choices. A mixed-agent model of choice indicated that silencing the FOF caused a change in the curvature of the rats’ utility function (U=Vρ). Consistent with this finding, single-neuron and population analyses of neural activity confirmed that the FOF encodes the lottery value on each trial. A dynamical model, which accounts for electrophysiological and silencing results, suggests that the FOF represents the current lottery value to compare against the remembered surebet value. These results demonstrate that the FOF is a critical node in the neural circuit for the dynamic representation of action values for choice under risk.

DOI: 10.1038/s41593-023-01461-x

Source: https://www.nature.com/articles/s41593-023-01461-x

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex