小柯机器人

英国牛津大学Bernhard P. Staresina团队取得一项新突破。他们揭示了耦合的慢波、纺锤波和波纹如何协同调控人类睡眠期间神经元的活动和通信。这一研究成果发表在2023年7月10日出版的国际学术期刊《自然—神经科学》上。

使用颅内脑电图和人类海马体及周围内侧颞叶（MTL）区域的多单元活动记录，研究人员发现，在缓慢振荡（SO）向上状态的支配下，睡眠时纺锤波为波纹的产生设定了时间范围。这种顺序耦合会产生如下影响：（1）神经元放电率（FRs）的逐步增加；（2）局部神经元组件之间的短延迟交叉相关性和（3）跨区域MTL相互作用。

波动由SO和纺锤波触发，从而为与尖峰时刻相关的可塑性和系统整合建立了最佳条件。这些结果揭示了特定的睡眠节律顺序耦合如何协调人类睡眠期间神经元的活动和通讯。

据介绍，学习和可塑性依赖于睡眠期间对神经元回路的微调调节。一个尚未决的难题是，在没有外部刺激或意识的情况下，睡眠时大脑如何协FRs和回路内部及之间的通信以维持突触和系统巩固。

附：英文原文

Title: How coupled slow oscillations, spindles and ripples coordinate neuronal processing and communication during human sleep

Author: Staresina, Bernhard P., Niediek, Johannes, Borger, Valeri, Surges, Rainer, Mormann, Florian

Issue&Volume: 2023-07-10

Abstract: Learning and plasticity rely on fine-tuned regulation of neuronal circuits during offline periods. An unresolved puzzle is how the sleeping brain, in the absence of external stimulation or conscious effort, coordinates neuronal firing rates (FRs) and communication within and across circuits to support synaptic and systems consolidation. Using intracranial electroencephalography combined with multiunit activity recordings from the human hippocampus and surrounding medial temporal lobe (MTL) areas, we show that, governed by slow oscillation (SO) up-states, sleep spindles set a timeframe for ripples to occur. This sequential coupling leads to a stepwise increase in (1) neuronal FRs, (2) short-latency cross-correlations among local neuronal assemblies and (3) cross-regional MTL interactions. Triggered by SOs and spindles, ripples thus establish optimal conditions for spike-timing-dependent plasticity and systems consolidation. These results unveil how the sequential coupling of specific sleep rhythms orchestrates neuronal processing and communication during human sleep.

DOI: 10.1038/s41593-023-01381-w

Source: https://www.nature.com/articles/s41593-023-01381-w

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex