小柯机器人

瑞士洛桑大学Grégoire Courtine等研究人员合作完成使用脑脊柱接口的脊髓损伤后自然行走。相关论文于2023年5月24日在线发表在《自然》杂志上。

研究人员用大脑和脊髓之间的数字桥梁恢复了这种交流，使一个患有慢性四肢瘫痪的人能够在社区环境中自然站立和行走。这种脑脊柱接口（BSI）由完全植入的记录和刺激系统组成，在大脑皮层信号和硬膜外电刺激的模拟调制之间建立了直接联系，目标是参与产生行走的脊髓区域。一个高度可靠的BSI在几分钟内就能完成校准。这种可靠性在一年内一直保持稳定，包括在家中独立使用期间。参与者报告说，BSI能够自然地控制他的腿部运动，从而站立、行走、爬楼梯，甚至穿越复杂地形。

此外，由BSI支持的神经康复改善了神经系统的恢复。即使在关闭BSI的情况下，参与者也重新获得了拄着拐杖在地面上行走的能力。这个数字桥梁建立了一个框架，可用于恢复瘫痪后对运动的自然控制。

据介绍，脊髓损伤中断了大脑和产生行走的脊髓区域之间的交流，导致瘫痪。

附：英文原文

Title: Walking naturally after spinal cord injury using a brain–spine interface

Author: Lorach, Henri, Galvez, Andrea, Spagnolo, Valeria, Martel, Felix, Karakas, Serpil, Intering, Nadine, Vat, Molywan, Faivre, Olivier, Harte, Cathal, Komi, Salif, Ravier, Jimmy, Collin, Thibault, Coquoz, Laure, Sakr, Icare, Baaklini, Edeny, Hernandez-Charpak, Sergio Daniel, Dumont, Gregory, Buschman, Rik, Buse, Nicholas, Denison, Tim, van Nes, Ilse, Asboth, Leonie, Watrin, Anne, Struber, Lucas, Sauter-Starace, Fabien, Langar, Lilia, Auboiroux, Vincent, Carda, Stefano, Chabardes, Stephan, Aksenova, Tetiana, Demesmaeker, Robin, Charvet, Guillaume, Bloch, Jocelyne, Courtine, Grgoire

Issue&Volume: 2023-05-24

Abstract: A spinal cord injury interrupts the communication between the brain and the region of the spinal cord that produces walking, leading to paralysis1,2. Here, we restored this communication with a digital bridge between the brain and spinal cord that enabled an individual with chronic tetraplegia to stand and walk naturally in community settings. This brain–spine interface (BSI) consists of fully implanted recording and stimulation systems that establish a direct link between cortical signals3 and the analogue modulation of epidural electrical stimulation targeting the spinal cord regions involved in the production of walking4,5,6. A highly reliable BSI is calibrated within a few minutes. This reliability has remained stable over one year, including during independent use at home. The participant reports that the BSI enables natural control over the movements of his legs to stand, walk, climb stairs and even traverse complex terrains. Moreover, neurorehabilitation supported by the BSI improved neurological recovery. The participant regained the ability to walk with crutches overground even when the BSI was switched off. This digital bridge establishes a framework to restore natural control of movement after paralysis.

DOI: 10.1038/s41586-023-06094-5

Source: https://www.nature.com/articles/s41586-023-06094-5

Nature：《自然》，创刊于1869年。隶属于施普林格·自然出版集团，最新IF：69.504
官方网址：http://www.nature.com/
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