小柯机器人

新加坡南洋理工大学Tom J. Carney等研究人员合作揭示源自侧板中胚层的中鳍和成对鳍的起源。2023年5月24日，《自然》杂志在线发表了这一最新研究成果。

研究人员发现幼年斑马鱼非成对的肛门前鳍褶（PAFF）来自侧板中胚层（LPM），因此可能代表了中鳍和配对鳍之间的一个发育中间环节。研究人员追踪了圆口类和有颌类中LPM对PAFF的贡献，并支持了这是脊椎动物的一个古老特征的观点。最后，研究人员观察到PAFF可以通过增加骨形态发生蛋白的信号而分叉，产生LPM衍生的成对鳍褶。这项工作提供了证据，证明侧鳍褶可能作为胚胎原基而存在，并被细化为成对鳍。

据悉，成对附属肢体的发育是演化过程中的一个关键创新，促进了脊椎动物从水生到陆生的过渡。成对鳍的演化主要来源于LPM，一种假设是通过位于胸鳍和盆鳍区之间的一对侧鳍褶从非成对的中鳍衍生而来。虽然非成对鳍和成对鳍表现出类似的结构和分子特征，但在任何现存或已灭绝物种的幼体或成体中，没有确切的证据表明有成对的侧鳍褶。由于非成对鳍的核心成分被认为完全来自于中轴旁的中胚层，任何过渡都假定了鳍的发育程序与LPM的合作以及双边的重复。

附：英文原文

Title: A median fin derived from the lateral plate mesoderm and the origin of paired fins

Author: Tzung, Keh-Weei, Lalonde, Robert L., Prummel, Karin D., Mahabaleshwar, Harsha, Moran, Hannah R., Stundl, Jan, Cass, Amanda N., Le, Yao, Lea, Robert, Dorey, Karel, Tomecka, Monika J., Zhang, Changqing, Brombacher, Eline C., White, William T., Roehl, Henry H., Tulenko, Frank J., Winkler, Christoph, Currie, Peter D., Amaya, Enrique, Davis, Marcus C., Bronner, Marianne E., Mosimann, Christian, Carney, Tom J.

Issue&Volume: 2023-05-24

Abstract: The development of paired appendages was a key innovation during evolution and facilitated the aquatic to terrestrial transition of vertebrates. Largely derived from the lateral plate mesoderm (LPM), one hypothesis for the evolution of paired fins invokes derivation from unpaired median fins via a pair of lateral fin folds located between pectoral and pelvic fin territories1. Whilst unpaired and paired fins exhibit similar structural and molecular characteristics, no definitive evidence exists for paired lateral fin folds in larvae or adults of any extant or extinct species. As unpaired fin core components are regarded as exclusively derived from paraxial mesoderm, any transition presumes both co-option of a fin developmental programme to the LPM and bilateral duplication2. Here, we identify that the larval zebrafish unpaired pre-anal fin fold (PAFF) is derived from the LPM and thus may represent a developmental intermediate between median and paired fins. We trace the contribution of LPM to the PAFF in both cyclostomes and gnathostomes, supporting the notion that this is an ancient trait of vertebrates. Finally, we observe that the PAFF can be bifurcated by increasing bone morphogenetic protein signalling, generating LPM-derived paired fin folds. Our work provides evidence that lateral fin folds may have existed as embryonic anlage for elaboration to paired fins.

DOI: 10.1038/s41586-023-06100-w

Source: https://www.nature.com/articles/s41586-023-06100-w

Nature：《自然》，创刊于1869年。隶属于施普林格·自然出版集团，最新IF：69.504
官方网址：http://www.nature.com/
投稿链接：http://www.nature.com/authors/submit_manuscript.html