美国哥伦比亚大学Attila Losonczy和Tristan Geiller共同合作，近期取得重要工作进展。他们研究提出了海马循环网络学习过程中尖波涟漪（SWR）持续时间的抑制控制。相关研究成果2023年4月20日在线发表于《自然—神经科学》杂志上。
据介绍，海马CA3和CA2区的复发性兴奋性连接被认为在SWR的产生中起着关键作用，这是一种与学习和记忆巩固密切相关的电生理振荡。然而，目前尚不清楚抑制性中间神经元群体是如何在行为过程中调节这些事件的。
研究人员使用小鼠海马中大规模三维钙成像和回顾性分子鉴定，来表征SWR相关记忆巩固和空间导航过程中分子鉴定的CA3和CA2中间神经元活动。研究人员描述了在行为不同的大脑状态下的亚型和区域特异性反应，并发现SWR之前是表达胆囊收缩素的中间神经元活性降低，然后是表达细小白蛋白的篮状细胞活性增加。这些动态的大小与海马依赖性学习期间的SWR持续时间和行为相关。
总之，这些结果共同赋予了抑制回路在海马循环回路中协调操作和学习相关可塑性的亚型和区域特异性作用。
附：英文原文
Title: Inhibitory control of sharp-wave ripple duration during learning in hippocampal recurrent networks
Author: Vancura, Bert, Geiller, Tristan, Grosmark, Andres, Zhao, Vivian, Losonczy, Attila
Issue&Volume: 2023-04-20
Abstract: Recurrent excitatory connections in hippocampal regions CA3 and CA2 are thought to play a key role in the generation of sharp-wave ripples (SWRs), electrophysiological oscillations tightly linked with learning and memory consolidation. However, it remains unknown how defined populations of inhibitory interneurons regulate these events during behavior. Here, we use large-scale, three-dimensional calcium imaging and retrospective molecular identification in the mouse hippocampus to characterize molecularly identified CA3 and CA2 interneuron activity during SWR-associated memory consolidation and spatial navigation. We describe subtype- and region-specific responses during behaviorally distinct brain states and find that SWRs are preceded by decreased cholecystokinin-expressing interneuron activity and followed by increased parvalbumin-expressing basket cell activity. The magnitude of these dynamics correlates with both SWR duration and behavior during hippocampal-dependent learning. Together these results assign subtype- and region-specific roles for inhibitory circuits in coordinating operations and learning-related plasticity in hippocampal recurrent circuits.
DOI: 10.1038/s41593-023-01306-7
Source: https://www.nature.com/articles/s41593-023-01306-7
Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex
本期文章：《自然—神经科学》：Online/在线发表
