近日，美国加州大学教授Kheirbek, Mazen A.及其小组报道了背侧和腹侧海马体联想学习的神经动力学。2023年4月3日，国际知名学术期刊《自然—神经科学》发表了这一成果。
据介绍，动物能将线索与结果联系起来，并随着新信息的出现而更新这些联系。这一功能的实现需要海马体的辅助，但海马神经元如何跟踪线索-结果关联的变化目前仍不清楚。
使用双光子钙成像，研究人员在几天内跟踪了相同的dCA1和vCA1神经元，以确定气味-结果学习阶段的反应是如何演变的。最初，气味在dCA1中引发了强烈的反应，而在vCA1中，气味反应主要是在学习和嵌入有关配对结果的信息后出现的。这两个区域的种群活动随着学习迅速重组，然后稳定下来，将学习到的气味表征储存数天，即使在消亡或配对后也会产生不同的结果。
此外，当小鼠在行为控制下预期结果时，研究人员在CA1中发现了稳定、强大的信号，而当小鼠预期不可避免的厌恶结果时，则没有。
总之，这些结果显示了海马体如何编码、存储和更新习到的关联，并阐明了背侧和腹侧海马体的独特贡献。
附：英文原文
Title: Neural dynamics underlying associative learning in the dorsal and ventral hippocampus
Author: Biane, Jeremy S., Ladow, Max A., Stefanini, Fabio, Boddu, Sayi P., Fan, Austin, Hassan, Shazreh, Dundar, Naz, Apodaca-Montano, Daniel L., Zhou, Lexi Zichen, Fayner, Varya, Woods, Nicholas I., Kheirbek, Mazen A.
Issue&Volume: 2023-04-03
Abstract: Animals associate cues with outcomes and update these associations as new information is presented. This requires the hippocampus, yet how hippocampal neurons track changes in cue–outcome associations remains unclear. Using two-photon calcium imaging, we tracked the same dCA1 and vCA1 neurons across days to determine how responses evolve across phases of odor–outcome learning. Initially, odors elicited robust responses in dCA1, whereas, in vCA1, odor responses primarily emerged after learning and embedded information about the paired outcome. Population activity in both regions rapidly reorganized with learning and then stabilized, storing learned odor representations for days, even after extinction or pairing with a different outcome. Additionally, we found stable, robust signals across CA1 when mice anticipated outcomes under behavioral control but not when mice anticipated an inescapable aversive outcome. These results show how the hippocampus encodes, stores and updates learned associations and illuminates the unique contributions of dorsal and ventral hippocampus.
DOI: 10.1038/s41593-023-01296-6
Source: https://www.nature.com/articles/s41593-023-01296-6
Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex
本期文章：《自然—神经科学》：Online/在线发表
