小柯机器人

美国加州大学洛杉矶分校Dejan Markovic等研究人员合作开发出一种用于在自由活动的人类中进行闭环刺激和记录单神经元的可穿戴平台。相关论文于2023年2月20日在线发表在《自然—神经科学》杂志上。

研究人员开发了一种可穿戴的双向闭环神经调节系统（Neuro-stack），并用其记录了人类静止和动态行为期间的单神经元和局部场电位活动。结合高度灵活和可切化的刺激能力，Neuro-stack提供了一个机会来研究疾病的神经生理学基础，开发改进的反应性神经调节疗法，并探索人类自然行为中的大脑功能，从而桥接不同物种间数十年的神经科学发现。

据介绍，记录和刺激人类深部大脑活动的技术进步在神经科学领域带来了有影响力的发现，并促进了神经和精神疾病新疗法的发展。然而，进一步的进展受到了设备限制的阻碍，因为在人类自由运动行为中记录单神经元活动是不可能的。此外，目前批准用于人类的植入式神经刺激设备具有有限的刺激可编程性和全双联双向能力。

附：英文原文

Title: A wearable platform for closed-loop stimulation and recording of single-neuron and local field potential activity in freely moving humans

Author: Topalovic, Uros, Barclay, Sam, Ling, Chenkai, Alzuhair, Ahmed, Yu, Wenhao, Hokhikyan, Vahagn, Chandrakumar, Hariprasad, Rozgic, Dejan, Jiang, Wenlong, Basir-Kazeruni, Sina, Maoz, Sabrina L., Inman, Cory S., Stangl, Matthias, Gill, Jay, Bari, Ausaf, Fallah, Aria, Eliashiv, Dawn, Pouratian, Nader, Fried, Itzhak, Suthana, Nanthia, Markovic, Dejan

Issue&Volume: 2023-02-20

Abstract: Advances in technologies that can record and stimulate deep brain activity in humans have led to impactful discoveries within the field of neuroscience and contributed to the development of novel therapies for neurological and psychiatric disorders. Further progress, however, has been hindered by device limitations in that recording of single-neuron activity during freely moving behaviors in humans has not been possible. Additionally, implantable neurostimulation devices, currently approved for human use, have limited stimulation programmability and restricted full-duplex bidirectional capability. In this study, we developed a wearable bidirectional closed-loop neuromodulation system (Neuro-stack) and used it to record single-neuron and local field potential activity during stationary and ambulatory behavior in humans. Together with a highly flexible and customizable stimulation capability, the Neuro-stack provides an opportunity to investigate the neurophysiological basis of disease, develop improved responsive neuromodulation therapies, explore brain function during naturalistic behaviors in humans and, consequently, bridge decades of neuroscientific findings across species.

DOI: 10.1038/s41593-023-01260-4

Source: https://www.nature.com/articles/s41593-023-01260-4

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex