小柯机器人

加拿大麦吉尔大学Maziar Divangahi等研究人员合作发现，中性粒细胞衍生的12-HETE对肺泡巨噬细胞进行新生印记。相关论文于2023年1月4日在线发表在《自然》杂志上。

Title: Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE

Author: Pernet, Erwan, Sun, Sarah, Sarden, Nicole, Gona, Saideep, Nguyen, Angela, Khan, Nargis, Mawhinney, Martin, Tran, Kim A., Chronopoulos, Julia, Amberkar, Dnyandeo, Sadeghi, Mina, Grant, Alexandre, Wali, Shradha, Prevel, Renaud, Ding, Jun, Martin, James G., Thanabalasuriar, Ajitha, Yipp, Bryan G., Barreiro, Luis B., Divangahi, Maziar

Issue&Volume: 2023-01-04

Abstract: Resident-tissue macrophages (RTM) arise from embryonic precursors1,2, yet developmental signals shaping their longevity remain largely unknown. Here we demonstrated in mice genetically deficient in 12/15-LOX (Alox15-/-) that neonatal neutrophil-derived 12-HETE was required for self-renewal and maintenance of alveolar macrophages (AM) during lung development. Although the seeding and differentiation of AM progenitors remained intact, the absence of 12-HETE led to a significant reduction of AM in the adult lungs and enhanced senescence due to increased prostaglandin E2 (PGE2) production. A compromised AM compartment resulted in increased susceptibility to LPS-induced acute lung injury, pulmonary influenza A virus and SARS-CoV-2 infections. Our results highlight the complexity of prenatal RTM programming and reveal their dependency on in trans eicosanoid production by neutrophils for lifelong self-renewal.

DOI: 10.1038/s41586-022-05660-7

Source: https://www.nature.com/articles/s41586-022-05660-7

Nature：《自然》，创刊于1869年。隶属于施普林格·自然出版集团，最新IF：69.504
官方网址：http://www.nature.com/
投稿链接：http://www.nature.com/authors/submit_manuscript.html