以色列魏茨曼科学研究所Nachum Ulanovsky等研究人员合作揭示海马中自我和他人的背景和纯时间编码。2022年12月30日,《自然—神经科学》杂志在线发表了这项成果。
Title: Contextual and pure time coding for self and other in the hippocampus
Author: Omer, David B., Las, Liora, Ulanovsky, Nachum
Issue&Volume: 2022-12-30
Abstract: Navigation and episodic memory depend critically on representing temporal sequences. Hippocampal ‘time cells’ form temporal sequences, but it is unknown whether they represent context-dependent experience or time per se. Here we report on time cells in bat hippocampal area CA1, which, surprisingly, formed two distinct populations. One population of time cells generated different temporal sequences when the bat hung at different locations, thus conjunctively encoding spatial context and time—‘contextual time cells’. A second population exhibited similar preferred times across different spatial contexts, thus purely encoding elapsed time. When examining neural responses after the landing moment of another bat, in a social imitation task, we found time cells that encoded temporal sequences aligned to the other’s landing. We propose that these diverse time codes may support the perception of interval timing, episodic memory and temporal coordination between self and others.
DOI: 10.1038/s41593-022-01226-y
Source: https://www.nature.com/articles/s41593-022-01226-y
Nature Neuroscience:《自然—神经科学》,创刊于1998年。隶属于施普林格·自然出版集团,最新IF:28.771
官方网址:https://www.nature.com/neuro/
投稿链接:https://mts-nn.nature.com/cgi-bin/main.plex
本期文章:《自然—神经科学》:Online/在线发表