小柯机器人

美国密歇根大学Issam El Naqa等研究人员合作实现癌症治疗期间辐射剂量递送至肝脏的实时、容积式成像。该项研究成果于2023年1月2日在线发表在《自然—生物技术》杂志上。

Title: Real-time, volumetric imaging of radiation dose delivery deep into the liver during cancer treatment

Author: Zhang, Wei, Oraiqat, Ibrahim, Litzenberg, Dale, Chang, Kai-Wei, Hadley, Scott, Sunbul, Noora Ba, Matuszak, Martha M., Tichacek, Christopher J., Moros, Eduardo G., Carson, Paul L., Cuneo, Kyle C., Wang, Xueding, El Naqa, Issam

Issue&Volume: 2023-01-02

Abstract: Ionizing radiation acoustic imaging (iRAI) allows online monitoring of radiation’s interactions with tissues during radiation therapy, providing real-time, adaptive feedback for cancer treatments. We describe an iRAI volumetric imaging system that enables mapping of the three-dimensional (3D) radiation dose distribution in a complex clinical radiotherapy treatment. The method relies on a two-dimensional matrix array transducer and a matching multi-channel preamplifier board. The feasibility of imaging temporal 3D dose accumulation was first validated in a tissue-mimicking phantom. Next, semiquantitative iRAI relative dose measurements were verified in vivo in a rabbit model. Finally, real-time visualization of the 3D radiation dose delivered to a patient with liver metastases was accomplished with a clinical linear accelerator. These studies demonstrate the potential of iRAI to monitor and quantify the 3D radiation dose deposition during treatment, potentially improving radiotherapy treatment efficacy using real-time adaptive treatment.

DOI: 10.1038/s41587-022-01593-8

Source: https://www.nature.com/articles/s41587-022-01593-8

Nature Biotechnology：《自然—生物技术》，创刊于1996年。隶属于施普林格·自然出版集团，最新IF：68.164
官方网址：https://www.nature.com/nbt/
投稿链接：https://mts-nbt.nature.com/cgi-bin/main.plex