小柯机器人

美国斯坦福大学Zhenan Bao和Geoffrey C. Gurtner共同合作，近期取得重要工作进展。他们研究开发出整合传感器和刺激器的无线闭环智能绷带，可帮助改善伤口护理并加速伤口愈合。相关论文于2022年11月24日在线发表于《自然—生物技术》杂志上。

据介绍，基于多模式可穿戴设备的“智能”绷带可以实现实时生理监测和积极干预，以促进慢性伤口的愈合。然而，目前智能绷带技术在传感器和刺激器的结合方面发展有限。此外，虽然粘附电极对于稳健的信号传导至关重要，但是如果没可切换的粘性，现有粘附敷料的脱落可能导致对脆弱伤口组织的二次损伤。

研究人员通过开发一种灵活的生物电子系统来克服这些问题，该系统由无线供电的闭环传感和刺激电路组成，具有能够按需粘附和分离的皮肤界面水凝胶电极。在小鼠中，研究人员证明了新开发的伤口护理系统可以连续监测皮肤阻抗和温度，并根据伤口环境提供电刺激。在临床前伤口模型中，与对照组相比，治疗组愈合速度快了约25%，真皮重塑增强约50%。

此外，研究人员观察到单核细胞和巨噬细胞群体中促再生基因的激活，这可能会促进组织再生、新生血管形成和皮肤恢复。

附：英文原文

Title: Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing

Author: Jiang, Yuanwen, Trotsyuk, Artem A., Niu, Simiao, Henn, Dominic, Chen, Kellen, Shih, Chien-Chung, Larson, Madelyn R., Mermin-Bunnell, Alana M., Mittal, Smiti, Lai, Jian-Cheng, Saberi, Aref, Beard, Ethan, Jing, Serena, Zhong, Donglai, Steele, Sydney R., Sun, Kefan, Jain, Tanish, Zhao, Eric, Neimeth, Christopher R., Viana, Willian G., Tang, Jing, Sivaraj, Dharshan, Padmanabhan, Jagannath, Rodrigues, Melanie, Perrault, David P., Chattopadhyay, Arhana, Maan, Zeshaan N., Leeolou, Melissa C., Bonham, Clark A., Kwon, Sun Hyung, Kussie, Hudson C., Fischer, Katharina S., Gurusankar, Gurupranav, Liang, Kui, Zhang, Kailiang, Nag, Ronjon, Snyder, Michael P., Januszyk, Michael, Gurtner, Geoffrey C., Bao, Zhenan

Issue&Volume: 2022-11-24

Abstract: ‘Smart’ bandages based on multimodal wearable devices could enable real-time physiological monitoring and active intervention to promote healing of chronic wounds. However, there has been limited development in incorporation of both sensors and stimulators for the current smart bandage technologies. Additionally, while adhesive electrodes are essential for robust signal transduction, detachment of existing adhesive dressings can lead to secondary damage to delicate wound tissues without switchable adhesion. Here we overcome these issues by developing a flexible bioelectronic system consisting of wirelessly powered, closed-loop sensing and stimulation circuits with skin-interfacing hydrogel electrodes capable of on-demand adhesion and detachment. In mice, we demonstrate that our wound care system can continuously monitor skin impedance and temperature and deliver electrical stimulation in response to the wound environment. Across preclinical wound models, the treatment group healed ~25% more rapidly and with ~50% enhancement in dermal remodeling compared with control. Further, we observed activation of proregenerative genes in monocyte and macrophage cell populations, which may enhance tissue regeneration, neovascularization and dermal recovery.

DOI: 10.1038/s41587-022-01528-3

Source: https://www.nature.com/articles/s41587-022-01528-3

Nature Biotechnology：《自然—生物技术》，创刊于1996年。隶属于施普林格·自然出版集团，最新IF：68.164
官方网址：https://www.nature.com/nbt/
投稿链接：https://mts-nbt.nature.com/cgi-bin/main.plex