加拿大卡尔加里大学Paul Kubes、Justin F. Deniset等研究人员合作发现一条对感染后修复至关重要的单核细胞-瘦素-血管生成途径。该研究于2022年8月10日在线发表于国际一流学术期刊《自然》。
Author: Kratofil, Rachel M., Shim, Hanjoo B., Shim, Raymond, Lee, Woo Yong, Labit, Elodie, Sinha, Sarthak, Keenan, Catherine M., Surewaard, Bas G. J., Noh, Ji Yeon, Sun, Yuxiang, Sharkey, Keith A., Mack, Matthias, Biernaskie, Jeff, Deniset, Justin F., Kubes, Paul
Issue&Volume: 2022-08-10
Abstract: During infection, inflammatory monocytes are thought to be key for bacterial eradication, but this is hard to reconcile with the large numbers of neutrophils that are recruited for each monocyte that migrates to the afflicted tissue, and the much more robust microbicidal functions of the neutrophils. However, unlike neutrophils, monocytes have the capacity to convert to situationally specific macrophages that may have critical functions beyond infection control1,2. Here, using a foreign body coated with Staphylococcus aureus and imaging over time from cutaneous infection to wound resolution, we show that monocytes and neutrophils are recruited in similar numbers with low-dose infection but not with high-dose infection, and form a localization pattern in which monocytes surround the infection site, whereas neutrophils infiltrate it. Monocytes did not contribute to bacterial clearance but converted to macrophages that persisted for weeks after infection, regulating hypodermal adipocyte expansion and production of the adipokine hormone leptin. In infected monocyte-deficient mice there was increased persistent hypodermis thickening and an elevated leptin level, which drove overgrowth of dysfunctional blood vasculature and delayed healing, with a thickened scar. Ghrelin, which opposes leptin function3, was produced locally by monocytes, and reduced vascular overgrowth and improved healing post-infection. In sum, we find that monocytes function as a cellular rheostat by regulating leptin levels and revascularization during wound repair.
DOI: 10.1038/s41586-022-05044-x
Source: https://www.nature.com/articles/s41586-022-05044-x
Nature:《自然》,创刊于1869年。隶属于施普林格·自然出版集团,最新IF:69.504
官方网址:http://www.nature.com/
投稿链接:http://www.nature.com/authors/submit_manuscript.html
本期文章:《自然》:Online/在线发表