小柯机器人

研究揭示小鼠分层视觉网络发展的模块化策略
2022-08-07 11:25

日本东京大学Kenichi Ohki等研究人员合作揭示小鼠分层视觉网络发展的模块化策略。2022年8月3日,《自然》杂志在线发表了这项成果。

研究人员表明,从小鼠视网膜到初级视觉皮层(V1)或背/腹高级视觉区(HVA)的神经通路通过低阶或高阶丘脑核在皮层连接之前形成平行模块。随后,V1和HVA之间的皮层连接出现,将这些模块结合起来。传播最初平行模块的视网膜活动对于建立视网膜模块间的连接是必要的。因此,视觉网络的发展是以模块化的方式进行的,包括平行模块的最初建立和随后的合并。这些结果提出了从高阶丘脑核到HVA的平行模块作为皮层腹侧和背侧流模板的可能性,并表明大脑有一个有效的策略来发展由许多区域组成的分层网络。

据悉,分层和平行网络是哺乳动物大脑的基本结构。在发育过程中,视觉系统中的低阶和高阶丘脑核和许多皮层区形成区间连接,并建立分层的背侧和腹侧流。关于视觉网络连线的发展,有一种假说涉及到一种顺序策略,即神经连接与层次结构一起从低级到高级区域依次形成。然而,这种顺序策略对于建立由众多区间连接组成的整个视觉网络来说是低效的。

附:英文原文

Title: Modular strategy for development of the hierarchical visual network in mice

Author: Murakami, Tomonari, Matsui, Teppei, Uemura, Masato, Ohki, Kenichi

Issue&Volume: 2022-08-03

Abstract: Hierarchical and parallel networks are fundamental structures of the mammalian brain1,2,3,4,5,6,7,8. During development, lower- and higher-order thalamic nuclei and many cortical areas in the visual system form interareal connections and build hierarchical dorsal and ventral streams9,10,11,12,13. One hypothesis for the development of visual network wiring involves a sequential strategy wherein neural connections are sequentially formed alongside hierarchical structures from lower to higher areas14,15,16,17. However, this sequential strategy would be inefficient for building the entire visual network comprising numerous interareal connections. We show that neural pathways from the mouse retina to primary visual cortex (V1) or dorsal/ventral higher visual areas (HVAs) through lower- or higher-order thalamic nuclei form as parallel modules before corticocortical connections. Subsequently, corticocortical connections among V1 and HVAs emerge to combine these modules. Retina-derived activity propagating the initial parallel modules is necessary to establish retinotopic inter-module connections. Thus, the visual network develops in a modular manner involving initial establishment of parallel modules and their subsequent concatenation. Findings in this study raise the possibility that parallel modules from higher-order thalamic nuclei to HVAs act as templates for cortical ventral and dorsal streams and suggest that the brain has an efficient strategy for the development of a hierarchical network comprising numerous areas.

DOI: 10.1038/s41586-022-05045-w

Source: https://www.nature.com/articles/s41586-022-05045-w

Nature:《自然》,创刊于1869年。隶属于施普林格·自然出版集团,最新IF:69.504
官方网址:http://www.nature.com/
投稿链接:http://www.nature.com/authors/submit_manuscript.html


本期文章:《自然》:Online/在线发表

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