小柯机器人

丹麦哥本哈根大学Maiken Nedergaard、Celia Kjaerby等研究人员合作发现，睡眠的记忆增强特性取决于去甲肾上腺素的震荡振幅。该研究于2022年7月7日在线发表于国际一流学术期刊《自然—神经科学》。

研究人员表示，睡眠有一个复杂的微观结构，包括微型唤醒、睡眠纺锤波和睡眠阶段之间的过渡。碎片化的睡眠会损害记忆的巩固，而富含纺锤波和德尔塔波的非快速眼动（NREM）睡眠和快速眼动（REM）睡眠则促进记忆的巩固。然而，微型唤醒和睡眠的记忆促进方面之间的关系仍然不清楚。

研究人员用小鼠的纤维测光法来研究了唤醒介质去甲肾上腺素（NE）的释放如何塑造睡眠的微结构。结果表明，微唤醒是在NREM睡眠期间以周期性模式产生的，乘着定位丘脑产生的细胞外NE的次低振荡的高峰，而NE振荡的下降阶段驱动纺锤波。NE振荡的振幅对塑造与记忆表现有关的睡眠微结构至关重要：NE的长时间下降促进了富含纺锤波的中间状态和快速眼动睡眠，但也与觉醒有关，而较短的NE下降则支持NREM睡眠和微唤醒。因此，NE振荡振幅可能是改善睡眠障碍的一个靶标。

附：英文原文

Title: Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine

Author: Kjaerby, Celia, Andersen, Mie, Hauglund, Natalie, Untiet, Verena, Dall, Camilla, Sigurdsson, Bjrn, Ding, Fengfei, Feng, Jiesi, Li, Yulong, Weikop, Pia, Hirase, Hajime, Nedergaard, Maiken

Issue&Volume: 2022-07-07

Abstract: Sleep has a complex micro-architecture, encompassing micro-arousals, sleep spindles and transitions between sleep stages. Fragmented sleep impairs memory consolidation, whereas spindle-rich and delta-rich non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep promote it. However, the relationship between micro-arousals and memory-promoting aspects of sleep remains unclear. In this study, we used fiber photometry in mice to examine how release of the arousal mediator norepinephrine (NE) shapes sleep micro-architecture. Here we show that micro-arousals are generated in a periodic pattern during NREM sleep, riding on the peak of locus-coeruleus-generated infraslow oscillations of extracellular NE, whereas descending phases of NE oscillations drive spindles. The amplitude of NE oscillations is crucial for shaping sleep micro-architecture related to memory performance: prolonged descent of NE promotes spindle-enriched intermediate state and REM sleep but also associates with awakenings, whereas shorter NE descents uphold NREM sleep and micro-arousals. Thus, the NE oscillatory amplitude may be a target for improving sleep in sleep disorders. Kjaerby and Andersen et al. show that norepinephrine (NE) plays profound roles in shaping sleep micro-architecture. NE slowly oscillates during sleep, with NE oscillatory amplitude being a major determinant of spindle-dependent memory consolidation and awakenings.

DOI: 10.1038/s41593-022-01102-9

Source: https://www.nature.com/articles/s41593-022-01102-9

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex