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一种雄性类固醇控制疟蚊的雌性性行为
2022-07-10 14:18
来源：小柯机器人

美国哈佛医学院Flaminia Catteruccia研究组发现，一种雄性类固醇控制疟蚊的雌性性行为。相关论文于2022年7月6日在线发表在《自然》杂志上。

研究人员表示。昆虫与脊椎动物不同，人们普遍认为它们缺乏偏向雄性的性类固醇激素。在疟蚊冈比亚按蚊中，20-羟基蜕皮酮（20E）似乎已经演化为当雌性合成时控制卵的发育，当雄性转移时诱发交配的反感。由于卵子发育和交配是重要的生殖特征，了解按蚊雌性如何整合这些激素信号可以促进新的疟疾控制计划的设计。
 
研究人员揭示了这些生殖功能是由不同的性类固醇通过蜕皮类固醇-激活/失活酶的复杂网络来调节。研究人员确定了一种雄性特有的氧化蜕皮类固醇，3-脱氢-20E（3D20E），它通过在性转移和去磷酸化激活后关闭雌性的性接受能力来保护父系。
 
值得注意的是，3D20E的转移还能诱导一种生殖基因的表达，在疟原虫感染期间保护卵子的发育，确保受感染雌性的健康。雌性衍生的20E不会引发性反感，相反，一旦抑制了20E的抑制性激酶，就会许可交配个体的排卵。确定这种雄性特有的昆虫类固醇激素及其在调节雌性性接受能力、生育能力和与疟原虫的相互作用表明，有可能降低传播疟疾的蚊子的繁殖成功率。
 
附：英文原文
 
Title: A male steroid controls female sexual behaviour in the malaria mosquito

Author: Peng, Duo, Kakani, Evdoxia G., Mameli, Enzo, Vidoudez, Charles, Mitchell, Sara N., Merrihew, Gennifer E., MacCoss, Michael J., Adams, Kelsey, Rinvee, Tasneem A., Shaw, W. Robert, Catteruccia, Flaminia

Issue&Volume: 2022-07-06

Abstract: Insects, unlike vertebrates, are widely believed to lack male-biased sex steroid hormones1. In the malaria mosquito Anopheles gambiae, the ecdysteroid 20-hydroxyecdysone (20E) appears to have evolved to both control egg development when synthesized by females2 and to induce mating refractoriness when sexually transferred by males3. Because egg development and mating are essential reproductive traits, understanding how Anopheles females integrate these hormonal signals can spur the design of new malaria control programs. Here we reveal that these reproductive functions are regulated by distinct sex steroids through a sophisticated network of ecdysteroid-activating/inactivating enzymes. We identify a male-specific oxidized ecdysteroid, 3-dehydro-20E (3D20E), which safeguards paternity by turning off female sexual receptivity following its sexual transfer and activation by dephosphorylation. Notably, 3D20E transfer also induces expression of a reproductive gene that preserves egg development during Plasmodium infection, ensuring fitness of infected females. Female-derived 20E does not trigger sexual refractoriness but instead licenses oviposition in mated individuals once a 20E-inhibiting kinase is repressed. Identifying this male-specific insect steroid hormone and its roles in regulating female sexual receptivity, fertility and interactions with Plasmodium parasites suggests the possibility for reducing the reproductive success of malaria-transmitting mosquitoes.

DOI: 10.1038/s41586-022-04908-6

Source: https://www.nature.com/articles/s41586-022-04908-6

Nature：《自然》，创刊于1869年。隶属于施普林格·自然出版集团，最新IF：69.504
官方网址：http://www.nature.com/
投稿链接：http://www.nature.com/authors/submit_manuscript.html


本期文章：《自然》：Online/在线发表

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