小柯机器人

科学家开发出连续转动化学能驱动的分子马达
2022-07-10 14:12

近日,中山大学赵德鹏和荷兰格罗宁根大学Ben L. Feringa等研究人员合作开发出连续转动化学能驱动的分子马达。该项研究成果于2022年7月6日在线发表在《自然》杂志上。

研究人员展示了一个具有三个不同立体化学元件的单手性双芳基马达-3,它是一个旋转马达,在化学燃料的驱动下,两个芳基围绕一个单键轴进行重复和单向的360°旋转。它依次进行酯环化、螺旋反转和开环,在自主旋转周期内实现高达99%的单向性。该分子旋转马达可以在两种模式下运行:i)与化学燃料的脉冲和酸碱振荡同步运动;ii)在有化学燃料的情况下,在略带碱性的水环境下自主运动。这种旋转马达的设计具有对旋转方向的内在控制,为自主运动提供简单的化学燃料,以及近乎完美的单向性,说明了未来多组件机器执行机械功能的潜力。
 
据悉,生物系统主要利用化学能来驱动自主分子马达,从而使系统失去平衡。从旋转马达如细菌鞭毛马达和三磷酸腺苷(ATP)合成酶中获得灵感,并在光能驱动的单向旋转分子马达的巨大成功基础上,科学家们一直追求设计完全由化学能驱动的合成分子马达。然而,设计使用化学燃料自主运行的人造旋转分子马达,同时具有内在的结构设计元素,从而允许像ATP合成酶一样进行360°的单向旋转运动,仍然具有挑战性。
 
附:英文原文
 
Title: Intrinsically unidirectional chemically fuelled rotary molecular motors

Author: Mo, Ke, Zhang, Yu, Dong, Zheng, Yang, Yuhang, Ma, Xiaoqiang, Feringa, Ben L., Zhao, Depeng

Issue&Volume: 2022-07-06

Abstract: Biological systems mainly utilize chemical energy to fuel autonomous molecular motors enabling to drive the system out-of-equilibrium1. Taking inspiration from rotary motors such as the bacterial flagellar motor2 and adenosine triphosphate (ATP) synthase3 and building on the great success of light-powered unidirectional rotary molecular motors4-6, scientists have pursued the design of synthetic molecular motors solely driven by chemical energy7-13. However, designing artificial rotary molecular motors operating autonomously using a chemical fuel and simultaneously featuring the intrinsic structural design elements to allow full 360° unidirectional rotary motion like ATP synthase remains challenging. Here, we show that a homochiral biaryl Motor-3, with three distinct stereochemical elements, is a rotary motor that undergoes repetitive and unidirectional 360° rotation of the two aryl groups around a single bond axle driven by a chemical fuel. It undergoes sequential ester cyclization, helix inversion and ring-opening, and up to 99% unidirectionality is realized over the autonomous rotary cycle. The molecular rotary motor can be operated in two modes: i) synchronized motion with pulses of a chemical fuel and acid-base oscillations; ii) autonomous motion in the presence of a chemical fuel under slightly basic aqueous conditions. This rotary motor design with intrinsic control over direction of rotation, simple chemical fueling for autonomous motion and near perfect unidirectionality illustrates the potential towards future generations multicomponent machines to perform mechanical functions.

DOI: 10.1038/s41586-022-05033-0

Source: https://www.nature.com/articles/s41586-022-05033-0

 

Nature:《自然》,创刊于1869年。隶属于施普林格·自然出版集团,最新IF:69.504
官方网址:http://www.nature.com/
投稿链接:http://www.nature.com/authors/submit_manuscript.html


本期文章:《自然》:Online/在线发表

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