小柯机器人

美国波士顿儿童医院Fernando D. Camargo团队近期取得重要工作进展，他们研究发现了胚胎产生的血液祖细胞的终生多系贡献。相关论文于2022年6月15日在线发表于《自然》杂志上。

在这里，研究人员使用原位条形码和经典命运图谱来评估小鼠成年血液的发育和克隆起源。他们的分析揭示了早期的祖细胞规范浪潮——独立于传统的HSC——在EHT之后不久就开始了。这些胚胎多能祖细胞(eMPPs)主要驱动年轻成人的造血功能，随着时间的推移，其贡献逐渐减少，但会伴随一生，并且是淋巴输出的主要来源。假定的eMPPs在动脉内造血细胞簇中被指定，代表了最早的造血祖细胞的一种命运。总的来说，他们的研究结果揭示了在最终波段的功能异质性，导致了不同的成年血液来源。

据了解，造血干细胞(HSCs)在胚胎中从动脉内皮产生，这一过程被称为内皮-造血转化(EHT)。这个过程会产生数百个造血祖细胞，其中一小部分会继续发展成为最终的 HSCs。一般认为，大多数成人血液来源于 HSCs，但其他祖细胞在多大程度上促进了成人造血尚不清楚。

附：英文原文

Title: Lifelong multilineage contribution by embryonic-born blood progenitors

Author: Patel, Sachin H., Christodoulou, Constantina, Weinreb, Caleb, Yu, Qi, da Rocha, Edroaldo Lummertz, Pepe-Mooney, Brian J., Bowling, Sarah, Li, Li, Osorio, Fernando G., Daley, George Q., Camargo, Fernando D.

Issue&Volume: 2022-06-15

Abstract: Haematopoietic stem cells (HSCs) arise in the embryo from the arterial endothelium through a process known as the endothelial-to-haematopoietic transition (EHT)1,2,3,4. This process generates hundreds of blood progenitors, of which a fraction go on to become definitive HSCs. It is generally thought that most adult blood is derived from those HSCs, but to what extent other progenitors contribute to adult haematopoiesis is not known. Here we use in situ barcoding and classical fate mapping to assess the developmental and clonal origins of adult blood in mice. Our analysis uncovers an early wave of progenitor specification—independent of traditional HSCs—that begins soon after EHT. These embryonic multipotent progenitors (eMPPs) predominantly drive haematopoiesis in the young adult, have a decreasing yet lifelong contribution over time and are the predominant source of lymphoid output. Putative eMPPs are specified within intra-arterial haematopoietic clusters and represent one fate of the earliest haematopoietic progenitors. Altogether, our results reveal functional heterogeneity during the definitive wave that leads to distinct sources of adult blood.

DOI: 10.1038/s41586-022-04804-z

Source: https://www.nature.com/articles/s41586-022-04804-z

Nature：《自然》，创刊于1869年。隶属于施普林格·自然出版集团，最新IF：69.504
官方网址：http://www.nature.com/
投稿链接：http://www.nature.com/authors/submit_manuscript.html