小柯机器人

美国斯坦福大学鲍哲南、Xiaoke Chen等研究人员合作开发出用于大脑和肠道的组织样神经递质传感器。2022年6月1日出版的《自然》杂志发表了这项成果。

研究人员报道了一种模仿组织、可拉伸的神经化学生物界面，称为NeuroString，它是通过将金属复合聚酰亚胺激光图案化为嵌入弹性体的相互连接的石墨烯/纳米粒子网络而制备的。NeuroString传感器允许在行为小鼠的大脑中进行慢性实时、多通道和多路单胺传感，以及在没有不良刺激和扰乱蠕动的情况下测量肠道中血清素的动态。该研究所描述的弹性和保形生物传感界面在研究神经递质对肠道微生物的影响、脑-肠交流方面具有广泛的潜力，并可能最终扩展到整个身体其他软器官的生物分子传感。

据了解，神经递质在调节中枢神经系统以及外周（包括胃肠道）的神经回路动态方面发挥着重要作用。它们的实时监测将为了解神经功能和诊断疾病提供关键信息。然而，监测体内神经递质动态的生物电子工具，特别是在肠道神经系统中，还没有得到充分的发展。这主要是由于能够检查柔软、复杂和活动器官的生物传感工具有限。

附：英文原文

Title: A tissue-like neurotransmitter sensor for the brain and gut

Author: Li, Jinxing, Liu, Yuxin, Yuan, Lei, Zhang, Baibing, Bishop, Estelle Spear, Wang, Kecheng, Tang, Jing, Zheng, Yu-Qing, Xu, Wenhui, Niu, Simiao, Beker, Levent, Li, Thomas L., Chen, Gan, Diyaolu, Modupeola, Thomas, Anne-Laure, Mottini, Vittorio, Tok, Jeffrey B.-H., Dunn, James C. Y., Cui, Bianxiao, Paca, Sergiu P., Cui, Yi, Habtezion, Aida, Chen, Xiaoke, Bao, Zhenan

Issue&Volume: 2022-06-01

Abstract: Neurotransmitters play essential roles in regulating neural circuit dynamics both in the central nervous system as well as at the peripheral, including the gastrointestinal tract1,2,3. Their real-time monitoring will offer critical information for understanding neural function and diagnosing disease1,2,3. However, bioelectronic tools to monitor the dynamics of neurotransmitters in vivo, especially in the enteric nervous systems, are underdeveloped. This is mainly owing to the limited availability of biosensing tools that are capable of examining soft, complex and actively moving organs. Here we introduce a tissue-mimicking, stretchable, neurochemical biological interface termed NeuroString, which is prepared by laser patterning of a metal-complexed polyimide into an interconnected graphene/nanoparticle network embedded in an elastomer. NeuroString sensors allow chronic in vivo real-time, multichannel and multiplexed monoamine sensing in the brain of behaving mouse, as well as measuring serotonin dynamics in the gut without undesired stimulations and perturbing peristaltic movements. The described elastic and conformable biosensing interface has broad potential for studying the impact of neurotransmitters on gut microbes, brain–gut communication and may ultimately be extended to biomolecular sensing in other soft organs across the body.

DOI: 10.1038/s41586-022-04615-2

Source: https://www.nature.com/articles/s41586-022-04615-2

Nature：《自然》，创刊于1869年。隶属于施普林格·自然出版集团，最新IF：69.504
官方网址：http://www.nature.com/
投稿链接：http://www.nature.com/authors/submit_manuscript.html