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研究揭示感觉皮质编码和区域间通信的新兴可靠性
2022-05-22 22:09

美国斯坦福大学Mark J. Schnitzer、Sadegh Ebrahimi等研究人员合作揭示感觉皮质编码和区域间通信的新兴可靠性。2022年5月19日,国际知名学术期刊《自然》在线发表了这一成果。

研究人员对小鼠执行视觉辨别任务的8个新皮层区域的神经元活动同时进行了5天的成像,产生了超过21000个神经元的纵向记录。分析显示,整个新皮层的事件序列从静止状态开始,到感知的早期阶段,并通过任务反应的形成。在静止状态下,新皮层有一种功能连接模式,通过共享活动共变的区域组来识别。在感觉刺激开始后约200毫秒内,这种连接重新排列,不同区域共享共变和任务相关信息。
 
在这个短暂的状态中(大约持续300毫秒),区域间的感觉数据传输和感觉编码的冗余都达到了顶峰,反映了任务相关神经元之间相关波动的短暂增加。刺激开始后约0.5秒,视觉表征达到一个更稳定的形式,其结构对单个细胞反应中突出的、逐日的变化是强大的。在刺激出现约1秒后,一个全局波动模式传达了小鼠对每个受检区域即将作出的反应,并与携带感觉数据的模式正交。
 
总的来说,新皮层通过在感知开始时感觉编码冗余的短暂提升、对细胞变异性稳健的神经群体编码以及广泛的区域间波动模式来支持感觉性能,这些模式以不干扰的渠道传递感觉数据和任务反应。
 
据了解,可靠的感觉辨别必须来自高保真的神经表征和脑区之间的交流。然而,新皮层感觉处理如何克服神经元感觉反应的巨大变异性仍未确定。
 
附:英文原文
 
Title: Emergent reliability in sensory cortical coding and inter-area communication

Author: Ebrahimi, Sadegh, Lecoq, Jrme, Rumyantsev, Oleg, Tasci, Tugce, Zhang, Yanping, Irimia, Cristina, Li, Jane, Ganguli, Surya, Schnitzer, Mark J.

Issue&Volume: 2022-05-19

Abstract: Reliable sensory discrimination must arise from high-fidelity neural representations and communication between brain areas. However, how neocortical sensory processing overcomes the substantial variability of neuronal sensory responses remains undetermined1,2,3,4,5,6. Here we imaged neuronal activity in eight neocortical areas concurrently and over five days in mice performing a visual discrimination task, yielding longitudinal recordings of more than 21,000 neurons. Analyses revealed a sequence of events across the neocortex starting from a resting state, to early stages of perception, and through the formation of a task response. At rest, the neocortex had one pattern of functional connections, identified through sets of areas that shared activity cofluctuations7,8. Within about 200ms after the onset of the sensory stimulus, such connections rearranged, with different areas sharing cofluctuations and task-related information. During this short-lived state (approximately 300 ms duration), both inter-area sensory data transmission and the redundancy of sensory encoding peaked, reflecting a transient increase in correlated fluctuations among task-related neurons. By around 0.5s after stimulus onset, the visual representation reached a more stable form, the structure of which was robust to the prominent, day-to-day variations in the responses of individual cells. About 1s into stimulus presentation, a global fluctuation mode conveyed the upcoming response of the mouse to every area examined and was orthogonal to modes carrying sensory data. Overall, the neocortex supports sensory performance through brief elevations in sensory coding redundancy near the start of perception, neural population codes that are robust to cellular variability, and widespread inter-area fluctuation modes that transmit sensory data and task responses in non-interfering channels.

DOI: 10.1038/s41586-022-04724-y

Source: https://www.nature.com/articles/s41586-022-04724-y

Nature:《自然》,创刊于1869年。隶属于施普林格·自然出版集团,最新IF:69.504
官方网址:http://www.nature.com/
投稿链接:http://www.nature.com/authors/submit_manuscript.html


本期文章:《自然》:Online/在线发表

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