小柯机器人

深圳华大基因研究院刘龙奇等研究人员合作绘制出非人灵长类猕猴的细胞转录组图谱。该项研究成果于2022年4月13日在线发表在《自然》杂志上。

研究人员提出了一个大规模的细胞转录组图谱，包括来自成年人类灵长类动物（NHP）猕猴45个组织的超过100万个细胞。这个数据集提供了一个庞大的注释资源来研究一个在系统发育上与人类接近的物种。为了证明该图集的实用性，研究人员重建了驱动Wnt信号的细胞-细胞相互作用网络，绘制了导致人类传染病的病毒的受体和共受体的分布图，并将这些数据与人类遗传病的同源物相交，以建立潜在的临床关联。这个猕猴细胞图谱构成了未来人类和NHP研究的一个重要参考。

据悉，研究NHP的组织组成和功能对于了解人类自身的性质至关重要。

附：英文原文

Title: Cell transcriptomic atlas of the non-human primate Macaca fascicularis

Author: Han, Lei, Wei, Xiaoyu, Liu, Chuanyu, Volpe, Giacomo, Zhuang, Zhenkun, Zou, Xuanxuan, Wang, Zhifeng, Pan, Taotao, Yuan, Yue, Zhang, Xiao, Fan, Peng, Guo, Pengcheng, Lai, Yiwei, Lei, Ying, Liu, Xingyuan, Yu, Feng, Shangguan, Shuncheng, Lai, Guangyao, Deng, Qiuting, Liu, Ya, Wu, Liang, Shi, Quan, Yu, Hao, Huang, Yunting, Cheng, Mengnan, Xu, Jiangshan, Liu, Yang, Wang, Mingyue, Wang, Chunqing, Zhang, Yuanhang, Xie, Duo, Yang, Yunzhi, Yu, Yeya, Zheng, Huiwen, Wei, Yanrong, Huang, Fubaoqian, Lei, Junjie, Huang, Waidong, Zhu, Zhiyong, Lu, Haorong, Wang, Bo, Wei, Xiaofeng, Chen, Fengzhen, Yang, Tao, Du, Wensi, Chen, Jing, Xu, Shibo, An, Juan, Ward, Carl, Wang, Zongren, Pei, Zhong, Wong, Chi-Wai, Liu, Xiaolei, Zhang, Huafeng, Liu, Mingyuan, Qin, Baoming, Schambach, Axel

Issue&Volume: 2022-04-13

Abstract: Studying tissue composition and function in non-human primates (NHPs) is crucial to understand the nature of our own species. Here we present a large-scale cell transcriptomic atlas that encompasses over 1 million cells from 45 tissues of the adult NHP Macaca fascicularis. This dataset provides a vast annotated resource to study a species phylogenetically close to humans. To demonstrate the utility of the atlas, we have reconstructed the cell–cell interaction networks that drive Wnt signalling across the body, mapped the distribution of receptors and co-receptors for viruses causing human infectious diseases, and intersected our data with human genetic disease orthologues to establish potential clinical associations. Our M.fascicularis cell atlas constitutes an essential reference for future studies in humans and NHPs.

DOI: 10.1038/s41586-022-04587-3

Source: https://www.nature.com/articles/s41586-022-04587-3

Nature：《自然》，创刊于1869年。隶属于施普林格·自然出版集团，最新IF：69.504
官方网址：http://www.nature.com/
投稿链接：http://www.nature.com/authors/submit_manuscript.html