小柯机器人

美国纽约大学Claude Desplan、Nikolaos Konstantinides等研究人员合作揭示果蝇视觉系统中一个完整的时间性转录因子序列。相关论文于2022年4月6日在线发表在《自然》杂志上。

Author: Konstantinides, Nikolaos, Holguera, Isabel, Rossi, Anthony M., Escobar, Aristides, Dudragne, Libaut, Chen, Yen-Chung, Tran, Thinh N., Martnez Jaimes, Azalia M., zel, Mehmet Neset, Simon, Flix, Shao, Zhiping, Tsankova, Nadejda M., Fullard, John F., Walldorf, Uwe, Roussos, Panos, Desplan, Claude

Issue&Volume: 2022-04-06

Abstract: The brain consists of thousands of neuronal types that are generated by stem cells producing different neuronal types as they age. In Drosophila, this temporal patterning is driven by the successive expression of temporal transcription factors (tTFs)1,2,3,4,5,6. Here we used single-cell mRNA sequencing to identify the complete series of tTFs that specify most Drosophila optic lobe neurons. We verify that tTFs regulate the progression of the series by activating the next tTF(s) and repressing the previous one(s), and also identify more complex mechanisms of regulation. Moreover, we establish the temporal window of origin and birth order of each neuronal type in the medulla and provide evidence that these tTFs are sufficient to explain the generation of all of the neuronal diversity in this brain region. Finally, we describe the first steps of neuronal differentiation and show that these steps are conserved in humans. We find that terminal differentiation genes, such as neurotransmitter-related genes, are present as transcripts, but not as proteins, in immature larval neurons. This comprehensive analysis of a temporal series of tTFs in the optic lobe offers mechanistic insights into how tTF series are regulated, and how they can lead to the generation of a complete set of neurons.

DOI: 10.1038/s41586-022-04564-w

Source: https://www.nature.com/articles/s41586-022-04564-w

Nature：《自然》，创刊于1869年。隶属于施普林格·自然出版集团，最新IF：69.504
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