小柯机器人

近日，荷兰乌特勒支大学Hilleke E. Hulshoff Pol、Rachel M. Brouwer等研究人员合作揭示与整个生命期大脑结构纵向变化有关的遗传变体。这一研究成果于2022年4月5日发表在国际学术期刊《自然—神经科学》上。

研究人员确定了影响大脑生长或萎缩速度的常见遗传变异，这是第一个关于整个生命周期内大脑形态变化的全基因组关联元分析。来自15,640人的纵向磁共振成像数据被用来计算15个大脑结构的变化率。最有力的鉴定基因GPR139、DACH1和APOE与代谢过程有关。研究人员证明了与抑郁症、精神分裂症、认知功能、失眠、身高、体重指数和吸烟的全局基因重叠。基因组的发现牵涉到早期大脑发育和神经退行性过程的大脑变化率。识别参与大脑结构变化的变体可能有助于确定大脑发育和衰老的生物途径。

据悉，人类的大脑结构在整个生命期都会发生变化。大脑生长或衰退速度的改变牵涉到大量的精神、发育和神经退行性疾病。

附：英文原文

Title: Genetic variants associated with longitudinal changes in brain structure across the lifespan

Author: Brouwer, Rachel M., Klein, Marieke, Grasby, Katrina L., Schnack, Hugo G., Jahanshad, Neda, Teeuw, Jalmar, Thomopoulos, Sophia I., Sprooten, Emma, Franz, Carol E., Gogtay, Nitin, Kremen, William S., Panizzon, Matthew S., Olde Loohuis, Loes M., Whelan, Christopher D., Aghajani, Moji, Alloza, Clara, Alns, Dag, Artiges, Eric, Ayesa-Arriola, Rosa, Barker, Gareth J., Bastin, Mark E., Blok, Elisabet, Ben, Erlend, Breukelaar, Isabella A., Bright, Joanna K., Buimer, Elizabeth E. L., Blow, Robin, Cannon, Dara M., Ciufolini, Simone, Crossley, Nicolas A., Damatac, Christienne G., Dazzan, Paola, de Mol, Casper L., de Zwarte, Sonja M. C., Desrivires, Sylvane, Daz-Caneja, Covadonga M., Doan, Nhat Trung, Dohm, Katharina, Frhner, Juliane H., Goltermann, Janik, Grigis, Antoine, Grotegerd, Dominik, Han, Laura K. M., Harris, Mathew A., Hartman, Catharina A., Heany, Sarah J., Heindel, Walter, Heslenfeld, Dirk J., Hohmann, Sarah, Ittermann, Bernd, Jansen, Philip R., Janssen, Joost, Jia, Tianye, Jiang, Jiyang, Jockwitz, Christiane, Karali, Temmuz, Keeser, Daniel, Koevoets, Martijn G. J. C., Lenroot, Rhoshel K., Malchow, Berend, Mandl, Ren C. W., Medel, Vicente, Meinert, Susanne, Morgan, Catherine A.

Issue&Volume: 2022-04-05

Abstract: Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging. Human brain structure changes throughout the lifespan. Brouwer et al. identified genetic variants that affect rates of brain growth and atrophy. The genes are linked to early brain development and neurodegeneration and suggest involvement of metabolic processes.

DOI: 10.1038/s41593-022-01042-4

Source: https://www.nature.com/articles/s41593-022-01042-4

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex