小柯机器人

2022年3月30日，美国加州大学伯克利分校Michael M. Yartsev研究团队在《自然》杂志发表论文，揭示自由飞行蝙蝠体内稳定的海马编码。

研究人员使用无线钙成像技术纵向监测了自由飞翔的蝙蝠背侧CA1海马神经元的活动，这些蝙蝠在熟悉的环境中进行高度可重复的飞行。研究人员发现，大多数神经元的参与和空间选择性在几天和几周内保持稳定。研究人员还发现，调谐的明显变化在很大程度上可以归因于蝙蝠飞行行为的变化。

最后，结果表明，在不同的室内照明条件下（开灯与关灯），在同一环境中导航的蝙蝠表现出飞行行为的巨大变化，这可能会给人一种神经元不稳定的错觉。然而，当类似的飞行路径在不同条件下进行比较时，海马区代码的稳定性持续存在。综上所述，结果表明，如果考虑到行为，海马的基本代码在不同的时间和不同的环境下是高度稳定的。

众所周知，海马体的神经活动反映了动物如何在环境中移动。虽然导航行为可能显示出相当的稳定性，但单个海马神经元的调谐稳定性仍不清楚。

附：英文原文

Title: A stable hippocampal code in freely flying bats

Author: Liberti, William A., Schmid, Tobias A., Forli, Angelo, Snyder, Madeleine, Yartsev, Michael M.

Issue&Volume: 2022-03-30

Abstract: Neural activity in the hippocampus is known to reflect how animals move through an environment1,2. Although navigational behaviour may show considerable stability3,4,5,6, the tuning stability of individual hippocampal neurons remains unclear7,8,9,10,11,12. Here we used wireless calcium imaging to longitudinally monitor the activity of dorsal CA1 hippocampal neurons in freely flying bats performing highly reproducible flights in a familiar environment. We find that both the participation and the spatial selectivity of most neurons remain stable over days and weeks. We also find that apparent changes in tuning can be largely attributed to variations in the flight behaviour of the bats. Finally, we show that bats navigating in the same environment under different room lighting conditions (lights on versus lights off) exhibit substantial changes in flight behaviour that can give the illusion of neuronal instability. However, when similar flight paths are compared across conditions, the stability of the hippocampal code persists. Taken together, we show that the underlying hippocampal code is highly stable over days and across contexts if behaviour is taken into account.

DOI: 10.1038/s41586-022-04560-0

Source: https://www.nature.com/articles/s41586-022-04560-0

Nature：《自然》，创刊于1869年。隶属于施普林格·自然出版集团，最新IF：69.504
官方网址：http://www.nature.com/
投稿链接：http://www.nature.com/authors/submit_manuscript.html